Anaprazole | proton pump inhibitor | gastric and duodenal ulcers

MedKoo Cat#: 124665 | Name: Anaprazole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Anaprazole is a novel proton pump inhibitor under development for the treatment of gastric and duodenal ulcers.

Chemical Structure

Anaprazole

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124665

Name: Anaprazole

CAS#: N/A

Chemical Formula: C21H24N2O4S

Exact Mass: 400.1500

Molecular Weight: 400.49

Elemental Analysis: C, 62.98; H, 6.04; N, 6.99; O, 15.98; S, 8.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ANAPRAZOLE; W6OO9ZB0FC; CHEMBL4651083

IUPAC/Chemical Name

2-((3-(3-methoxypropoxy)-2-methylbenzyl)sulfinyl)-6,7-dihydro-1H-benzofuro[5,6-d]imidazole

InChi Key

JYSIFLQJDVIWKM-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H24N2O4S/c1-14-16(5-3-6-19(14)26-9-4-8-25-2)13-28(24)21-22-17-11-15-7-10-27-20(15)12-18(17)23-21/h3,5-6,11-12H,4,7-10,13H2,1-2H3,(H,22,23)

SMILES Code

CC1=C(C=CC=C1OCCCOC)CS(=O)C2=NC3=C(N2)C=C4CCOC4=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 400.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tang C, Li L, Ma X, Wang J, Chen B, Dai X, Zhang Y, Chen X. Qualitative and quantitative determination of anaprazole and its major metabolites in human plasma. J Pharm Biomed Anal. 2020 May 10;183:113146. doi: 10.1016/j.jpba.2020.113146. Epub 2020 Feb 4. PMID: 32086126. 2: Shu X, Zhu Z, Fu Y, Zhang Z, Wang J, Li X, He S, Fan H, Liu S, Zhang G, Tang J, Huang C, Du Q, Wang X, Xu B, Du Y, Chen Q, Wang B, Chen Y, Duan X, Xie Y, Huo L, Hou X, Lu N. Mucosal Healing Effectiveness and Safety of Anaprazole, a Novel PPI, vs. Rabeprazole in Patients With Duodenal Ulcers: A Randomized Double- Blinded Multicenter Phase II Clinical Trial. Front Med (Lausanne). 2021 Jul 14;8:690995. doi: 10.3389/fmed.2021.690995. PMID: 34336894; PMCID: PMC8317206. 3: Zhu H, Pan X, Zhang L, Sun H, Fan H, Pan Z, Huang C, Shi Z, Ding J, Wang Q, Du Y, Lyu N, Li Z. Effect and safety of anaprazole in the treatment of duodenal ulcers: a randomized, rabeprazole-controlled, phase III non-inferiority study. Chin Med J (Engl). 2022 Dec 20;135(24):2941-2949. doi: 10.1097/CM9.0000000000002508. PMID: 36580650; PMCID: PMC10106214. 4: Ding S, Xie L, Wang L, Zhou C, Zhou S, Chen J, Zhu B, Liu Y, Zhu J, Zhang Z, Li T, Wang L, Zhang Z, Shao F. Pharmacokinetic Interaction of Anaprazole, Amoxicillin and Clarithromycin after Single-Dose Simultaneous Administration and the Effect of Adding Bismuth on Their Pharmacokinetics in Healthy Male Chinese Subjects. Eur J Drug Metab Pharmacokinet. 2023 Mar;48(2):121-132. doi: 10.1007/s13318-022-00810-8. Epub 2022 Dec 15. PMID: 36520316. 5: Liu F, Xu Y, Wang L, Ma X, Zhang Z, Zhuang X. Combined contributions of cytochrome P450s (CYPs) and non-enzymatic metabolism in the in vitro biotransformation of anaprazole, a novel proton pump inhibitor. Naunyn Schmiedebergs Arch Pharmacol. 2023 Aug;396(8):1759-1771. doi: 10.1007/s00210-023-02415-7. Epub 2023 Feb 27. PMID: 36847804.