Ritolukast | aerosol leukotriene D4 | LTD4 | receptor antagonist | CAS#111974-60-8

MedKoo Cat#: 124645 | Name: Ritolukast

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ritolukast (WY 48252) is an aerosol leukotriene D4 (LTD4) receptor antagonist.

Chemical Structure

Ritolukast

CAS#111974-60-8

Theoretical Analysis

MedKoo Cat#: 124645

Name: Ritolukast

CAS#: 111974-60-8

Chemical Formula: C17H13F3N2O3S

Exact Mass: 382.0600

Molecular Weight: 382.36

Elemental Analysis: C, 53.40; H, 3.43; F, 14.91; N, 7.33; O, 12.55; S, 8.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RITOLUKAST; Wy-48252; Ritolukastum; 111974-60-8; Ritolukast [USAN:INN]

IUPAC/Chemical Name

1,1,1-trifluoro-N-(3-(quinolin-2-ylmethoxy)phenyl)methanesulfonamide

InChi Key

GOHUJGMYCZDYDF-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H13F3N2O3S/c18-17(19,20)26(23,24)22-13-5-3-6-15(10-13)25-11-14-9-8-12-4-1-2-7-16(12)21-14/h1-10,22H,11H2

SMILES Code

C1=CC=C2C(=C1)C=CC(=N2)COC3=CC=CC(=C3)NS(=O)(=O)C(F)(F)F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 382.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hand JM, Auen MA, Chang J, Englebach IM. Prevention and reversal of aerosol LTD4-induced changes in guinea pig pulmonary mechanics by Wy-48252, an orally active LTD4/E4 receptor antagonist. Int Arch Allergy Appl Immunol. 1989;89(1):78-82. doi: 10.1159/000234927. PMID: 2731997. 2: Ellis JL, Undem BJ. Role of peptidoleukotrienes in capsaicin-sensitive sensory fibre-mediated responses in guinea-pig airways. J Physiol. 1991 May;436:469-84. doi: 10.1113/jphysiol.1991.sp018561. PMID: 2061842; PMCID: PMC1181516. 3: Barnette MS, Grous M. Characterization of the antigen-induced contraction of colonic smooth muscle from sensitized guinea pigs. Am J Physiol. 1992 Jan;262(1 Pt 1):G144-9. doi: 10.1152/ajpgi.1992.262.1.G144. PMID: 1733261. 4: Sjogren RW, Colleton C, Shea-Donohue T. Intestinal myoelectric response in two different models of acute enteric inflammation. Am J Physiol. 1994 Sep;267(3 Pt 1):G329-37. doi: 10.1152/ajpgi.1994.267.3.G329. PMID: 7943229. 5: O'Sullivan BP, Mong S. Binding of radiolabeled high affinity antagonist to leukotriene D4 receptor in guinea pig lung membranes: interconversion of agonist-receptor binding affinity states. Mol Pharmacol. 1989 Jun;35(6):795-802. PMID: 2543913.