SMD-3040 is a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity. SMD-3040 degrades SMARCA2 protein with a low nanomolar DC50 and Dmax > 90% and demonstrates an excellent degradation selectivity for SMARCA2 protein over SMARCA4 protein. It displays potent cell growth inhibitory activity in a panel of SMARCA4-deficient cancer cell lines and has much weaker activity in SMARCA4 wild-type cancer cell lines. SMD-3040 achieves strong tumor growth inhibition in two SMARCA4-deficient xenograft models at well-tolerated dose schedules.
MedKoo Cat#: 124442
Name: SMD-3040
CAS#: 3033109-92-8
Chemical Formula: C52H66N10O5S
Exact Mass: 942.4900
Molecular Weight: 943.23
Elemental Analysis: C, 66.22; H, 7.05; N, 14.85; O, 8.48; S, 3.40
The following data is based on the product molecular weight 943.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
