MedKoo Cat#: 124397 | Name: PHGDH-IN-3
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor.

Chemical Structure

PHGDH-IN-3
PHGDH-IN-3
CAS#2893778-31-7

Theoretical Analysis

MedKoo Cat#: 124397

Name: PHGDH-IN-3

CAS#: 2893778-31-7

Chemical Formula: C24H18FN3O4S2

Exact Mass: 495.0723

Molecular Weight: 495.54

Elemental Analysis: C, 58.17; H, 3.66; F, 3.83; N, 8.48; O, 12.91; S, 12.94

Price and Availability

Size Price Availability Quantity
200mg USD 1,550.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 3,950.00 2 Weeks
2g USD 5,950.00 2 Weeks
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Related CAS #
No Data
Synonym
PHGDH inhibitor D8; PHGDH-IN-D8; GLXC-26715; PHGDH-IN-3
IUPAC/Chemical Name
4-(N-(3-acetylphenyl)sulfamoyl)-N-(4-(3-fluorophenyl)thiazol-2-yl)benzamide
InChi Key
VUAMLKVINZWIJR-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H18FN3O4S2/c1-15(29)17-4-3-7-20(13-17)28-34(31,32)21-10-8-16(9-11-21)23(30)27-24-26-22(14-33-24)18-5-2-6-19(25)12-18/h2-14,28H,1H3,(H,26,27,30)
SMILES Code
CC(C1=CC=CC(NS(=O)(C2=CC=C(C=C2)C(NC3=NC(C4=CC=CC(F)=C4)=CS3)=O)=O)=C1)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 495.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Gao D, Tang S, Cen Y, Yuan L, Lan X, Li QH, Lin GQ, Huang M, Tian P. Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy. J Med Chem. 2023 Jan 12;66(1):285-305. doi: 10.1021/acs.jmedchem.2c01202. Epub 2023 Jan 3. PMID: 36594670.