IACS-52825 | DLK Inhibitor

MedKoo Cat#: 124281 | Name: IACS-52825

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IACS-52825 is a Potent and Selective DLK Inhibitor(IC50 = 107 nM) for Treatment of Chemotherapy-Induced Peripheral Neuropathy. IACS-52825 showed strongly effective reversal of mechanical allodynia in a mouse model of CIPN.

Chemical Structure

IACS-52825

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124281

Name: IACS-52825

CAS#: N/A

Chemical Formula: C16H13F7N4O2

Exact Mass: 426.0900

Molecular Weight: 426.29

Elemental Analysis: C, 45.08; H, 3.07; F, 31.20; N, 13.14; O, 7.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IACS-52825; IACS52825; IACS 52825

IUPAC/Chemical Name

(R)-1-(4-(6-amino-5-(trifluoromethoxy)pyridin-3-yl)-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-imidazol-2-yl)-2,2,2-trifluoroethan-1-ol

InChi Key

XUOJHVFYSAMHNK-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H13F7N4O2/c17-13-4-14(5-13,6-13)27-3-8(26-12(27)10(28)15(18,19)20)7-1-9(11(24)25-2-7)29-16(21,22)23/h1-3,10,28H,4-6H2,(H2,24,25)

SMILES Code

FC1(C2)CC2(N3C([C@@H](O)C(F)(F)F)=NC(C4=CN=C(N)C(OC(F)(F)F)=C4)=C3)C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 426.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Le K, Soth MJ, Cross JB, Liu G, Ray WJ, Ma J, Goodwani SG, Acton PJ, Buggia-Prevot V, Akkermans O, Barker J, Conner ML, Jiang Y, Liu Z, McEwan P, Warner-Schmidt J, Xu A, Zebisch M, Heijnen CJ, Abrahams B, Jones P. Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. J Med Chem. 2023 Jul 12. doi: 10.1021/acs.jmedchem.3c00788. Epub ahead of print. PMID: 37436942.