JPC0323 is a selective 5-HT2CR or dual 5-HT2CR/5-HT2AR positive allosteric modulator (PAM). JPC0323 exhibited on-target properties, acceptable plasma exposure and brain penetration, as well as negligible displacement to orth osteric sites of ∼50 GPCRs and transporters. Furthermore, JPC0323 suppressed novelty-induced locomotor activity in a 5-HT2CRdependent manner, suggesting 5-HT2CR PAM, but not 5-HT2AR, activity at the level of the whole organism at the employed doses of JPC0323.
MedKoo Cat#: 124272
Name: JPC0323
CAS#: N/A
Chemical Formula: C22H43NO4
Exact Mass: 385.3200
Molecular Weight: 385.59
Elemental Analysis: C, 68.53; H, 11.24; N, 3.63; O, 16.60
The following data is based on the product molecular weight 385.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
