MedKoo Cat#: 124271 | Name: HPG1860
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

HPG1860 is a potent full FXR agonist. HPG1860 shows high selectivity, favorable ADME and pharmacokinetics profile, along with favorable in vivo activities demonstrated in both rodent PD model and HFD-CCl4 model

Chemical Structure

HPG1860
HPG1860
CAS#2226133-29-3

Theoretical Analysis

MedKoo Cat#: 124271

Name: HPG1860

CAS#: 2226133-29-3

Chemical Formula: C27H26Cl2N4O4S

Exact Mass: 572.1100

Molecular Weight: 573.49

Elemental Analysis: C, 56.55; H, 4.57; Cl, 12.36; N, 9.77; O, 11.16; S, 5.59

Price and Availability

Size Price Availability Quantity
1mg USD 250.00 2 Weeks
5mg USD 550.00 2 Weeks
10mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
HPG1860; HPG-1860; HPG 1860
IUPAC/Chemical Name
(R)-2-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methyl)-2-methylpiperazin-1-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid
InChi Key
JPEHHEUXHNQIIX-CQSZACIVSA-N
InChi Code
InChI=1S/C27H26Cl2N4O4S/c1-14-12-32(8-9-33(14)27-30-24-20(36-2)10-16(26(34)35)11-21(24)38-27)13-17-23(31-37-25(17)15-6-7-15)22-18(28)4-3-5-19(22)29/h3-5,10-11,14-15H,6-9,12-13H2,1-2H3,(H,34,35)/t14-/m1/s1
SMILES Code
ClC1=CC=CC(Cl)=C1C2=NOC(C3CC3)=C2CN4CCN(C5=NC6=C(C=C(C(O)=O)C=C6OC)S5)[C@H](C)C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 573.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Mo C, Xu X, Zhang P, Peng Y, Zhao X, Chen S, Guo F, Xiong Y, Chu XJ, Xu X. Discovery of HPG1860, a Structurally Novel Nonbile Acid FXR Agonist Currently in Clinical Development for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2023 Jul 9. doi: 10.1021/acs.jmedchem.3c00456. Epub ahead of print. PMID: 37424079.