GW6340 | CAS#405910-78-3 | LXR agonist

MedKoo Cat#: 124253 | Name: GW6340

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW6340 is an intestinal-specific LXR agonist. GW6340 significantly promoted excretion of [(3)H]-sterol in feces by 52%, Intestinal-specific LXR agonism promotes macrophage RCT in vivo and that macrophage LXR itself plays an important, but not predominant, role in promoting RCT in response to an LXR agonist.

Chemical Structure

GW6340

CAS#405910-78-3

Theoretical Analysis

MedKoo Cat#: 124253

Name: GW6340

CAS#: 405910-78-3

Chemical Formula: C33H32ClF3N2O2

Exact Mass: 580.2104

Molecular Weight: 581.08

Elemental Analysis: C, 68.21; H, 5.55; Cl, 6.10; F, 9.81; N, 4.82; O, 5.51

Price and Availability

Size	Price	Availability
5mg	USD 95.00	Ready to ship
10mg	USD 165.00	Ready to ship
25mg	USD 350.00	Ready to Ship
50mg	USD 550.00	Ready to Ship
100mg	USD 950.00	Ready to ship
200mg	USD 1,450.00	Ready to ship
500mg	USD 2,450.00	Ready to ship

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Related CAS #

No Data

Synonym

GW6340; GW 6340; GW-6340

IUPAC/Chemical Name

2-(3-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetamide

InChi Key

ZVWVNNYZOBNFFJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C33H32ClF3N2O2/c34-32-27(15-8-17-30(32)33(35,36)37)22-39(18-9-19-41-28-16-7-10-24(20-28)21-31(38)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H2,38,40)

SMILES Code

O=C(CC1=CC(OCCCN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(C(F)(F)F)=C4Cl)=CC=C1)N

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#A24T05K01

QC Data

View QC data: current batch, Lot#A24T05K01

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

GW6340 is an intestinal-specific LXR agonist. To evaluate the effect of LXR activation specifically in small intestine on mRCT, wild-type mice were treated with either intestinal-specific LXR agonist (GW6340) or systemic LXR agonist (GW3965). Both GW3965 and GW6340 significantly promoted excretion of [(3)H]-sterol in feces by 162% and 52%, respectively. Yasuda T, Grillot D, Billheimer JT, Briand F, Delerive P, Huet S, Rader DJ. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):781-6.

In vitro activity:

TBD

In vivo activity:

Initial studies using the systemic LXR agonist GW3965 showed no promotion of macrophage reverse cholesterol transport (mRCT) in mice lacking LXR expression in the liver or intestine. Evaluating the effect of LXR activation specifically in the small intestine, both intestinal-specific (GW6340) and systemic (GW3965) LXR agonists significantly increased sterol excretion in feces. However, when assessing the necessity of macrophage LXR activation, mice with LXR alpha/beta knockout macrophages showed significantly reduced mRCT promotion with GW3965 treatment, highlighting the importance of macrophage LXR activation in this process.

	Solvent	mg/mL	mM
Solubility
	DMSO	100.0	172.10

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 581.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Yasuda T, Grillot D, Billheimer JT, Briand F, Delerive P, Huet S, Rader DJ. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):781-6. doi: 10.1161/ATVBAHA.109.195693. Epub 2010 Jan 28. PMID: 20110577; PMCID: PMC3137455.

In vitro protocol:

TBD

In vivo protocol: