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MedKoo Cat#: 124070 | Name: EGFR-IN-8
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

EGFR-IN-8 is a dual EGFR and c-Met inhibitor.

Chemical Structure

EGFR-IN-8
EGFR-IN-8
CAS#2407957-87-1

Theoretical Analysis

MedKoo Cat#: 124070

Name: EGFR-IN-8

CAS#: 2407957-87-1

Chemical Formula: C32H23ClF3N7O4

Exact Mass: 661.1452

Molecular Weight: 662.03

Elemental Analysis: C, 58.06; H, 3.50; Cl, 5.35; F, 8.61; N, 14.81; O, 9.67

Price and Availability

Size Price Availability Quantity
100mg USD 1,950.00 2 Weeks
200mg USD 2,950.00 2 Weeks
500mg USD 3,950.00 2 Weeks
1g USD 5,950.00 2 Weeks
2g USD 8,950.00 2 Weeks
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Related CAS #
No Data
Synonym
EGFR-IN-8; starbld0000884; CHEMBL4443455; AKOS040733075;
IUPAC/Chemical Name
N-(3-chloro-4-(5-(3-(3-(4-(cyclopropanecarboxamido)-3-(trifluoromethyl)phenyl)ureido)phenyl)-1,2,4-oxadiazol-3-yl)phenyl)nicotinamide
InChi Key
IIUNSVLRVWGJRM-UHFFFAOYSA-N
InChi Code
InChI=1S/C32H23ClF3N7O4/c33-25-15-22(38-29(45)19-4-2-12-37-16-19)8-10-23(25)27-42-30(47-43-27)18-3-1-5-20(13-18)39-31(46)40-21-9-11-26(24(14-21)32(34,35)36)41-28(44)17-6-7-17/h1-5,8-17H,6-7H2,(H,38,45)(H,41,44)(H2,39,40,46)
SMILES Code
O=C(NC1C=C(C2ON=C(C3C(Cl)=CC(NC(=O)C4C=NC=CC=4)=CC=3)N=2)C=CC=1)NC1C=CC(NC(=O)C2CC2)=C(C(F)(F)F)C=1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 662.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Dokla EME, Fang CS, Abouzid KAM, Chen CS. 1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC. Eur J Med Chem. 2019 Nov 15;182:111607. doi: 10.1016/j.ejmech.2019.111607. Epub 2019 Aug 9. PMID: 31446247.