MedKoo Cat#: 123938 | Name: SLU-10482

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SLU-10482 is an agent potentially useful for treatment of cryptosporidiosis. SLU-10482 has EC50 = 0.07 μΜ, which was found to be orally efficacious with an ED90 < 5 mg/kg BID in a Cryptosporidiuminfection mouse model, superior to SLU-2633.

Chemical Structure

SLU-10482
SLU-10482
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 123938

Name: SLU-10482

CAS#: N/A

Chemical Formula: C18H16F4N6O

Exact Mass: 408.1300

Molecular Weight: 408.36

Elemental Analysis: C, 52.94; H, 3.95; F, 18.61; N, 20.58; O, 3.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SLU-10482; SLU10482; SLU 10482
IUPAC/Chemical Name
1-(4-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperazin-1-yl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-one
InChi Key
NIBRKSRYSFJILK-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H16F4N6O/c19-14-2-1-12(9-13(14)18(20,21)22)10-17(29)27-7-5-26(6-8-27)16-4-3-15-24-23-11-28(15)25-16/h1-4,9,11H,5-8,10H2
SMILES Code
O=C(N1CCN(C2=NN3C(C=C2)=NN=C3)CC1)CC4=CC=C(F)C(C(F)(F)F)=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 408.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Schubert TJ, Oboh E, Peek H, Philo E, Teixeira JE, Stebbins EE, Miller P, Oliva J, Sverdrup FM, Griggs DW, Huston CD, Meyers MJ. Structure-Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against Cryptosporidium Reveals Remarkable Role of Fluorine. J Med Chem. 2023 Jun 2. doi: 10.1021/acs.jmedchem.3c00110. Epub ahead of print. PMID: 37267631.