Synonym
ARTD3/PARP3-IN-1; ARTD3; PARP3-IN-1; ARTD3/PARP3
IUPAC/Chemical Name
3-(4-oxo-1,4-dihydroquinazolin-2-yl)-N-(pyridin-2-ylmethyl)propanamide
InChi Key
LHJLGHGHHDKLMY-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H16N4O2/c22-16(19-11-12-5-3-4-10-18-12)9-8-15-20-14-7-2-1-6-13(14)17(23)21-15/h1-7,10H,8-9,11H2,(H,19,22)(H,20,21,23)
SMILES Code
O=C1N=C(CCC(NCC2=NC=CC=C2)=O)NC3=C1C=CC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
308.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A,
Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F. Poly(ADP-
ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and
mitotic progression. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2783-8. doi:
10.1073/pnas.1016574108. Epub 2011 Jan 26. PMID: 21270334; PMCID: PMC3041075.
2: Lindgren AE, Karlberg T, Thorsell AG, Hesse M, Spjut S, Ekblad T, Andersson
CD, Pinto AF, Weigelt J, Hottiger MO, Linusson A, Elofsson M, Schüler H. PARP
inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem
Biol. 2013 Aug 16;8(8):1698-703. doi: 10.1021/cb4002014. Epub 2013 Jun 25. PMID:
23742272.
3: Lindgren AE, Karlberg T, Ekblad T, Spjut S, Thorsell AG, Andersson CD, Nhan
TT, Hellsten V, Weigelt J, Linusson A, Schüler H, Elofsson M. Chemical probes to
study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of
the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem. 2013 Dec
12;56(23):9556-68. doi: 10.1021/jm401394u. Epub 2013 Nov 22. PMID: 24188023.
