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MedKoo Cat#: 408198 | Name: DOTA-NT-20.3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DOTA-NT-20.3 is a neurotensin (NTS) analogue and a ligand for 68Ga ion. 68Ga-DOTA-NT-20.3 PET images showed rapid tumor uptake and high contrast between the tumor and background with a fast blood clearance and a moderate accumulation in the kidneys. 68Ga-DOTA-NT-20.3 has a favorable pharmacokinetics and biodistribution profile, which results in high quality PET images in mice with subcutaneous or orthotopic grafted human pancreatic cancer. 68Ga-DOTA-NT-20.3 showed specific binding to NTSR1 of pancreatic cancer cells and provided higher PET detection of adenocarcinoma than 18F-FDG.

Chemical Structure

DOTA-NT-20.3
DOTA-NT-20.3
CAS#1262311-97-6

Theoretical Analysis

MedKoo Cat#: 408198

Name: DOTA-NT-20.3

CAS#: 1262311-97-6

Chemical Formula: C68H113N19O18

Exact Mass: 1483.8511

Molecular Weight: 1484.77

Elemental Analysis: C, 55.01; H, 7.67; N, 17.92; O, 19.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DOTA-NT-20.3; Ac-Lys-Pro-N-Me-Arg-Arg-Pro-Tyr-Tle-Leu-OH;
IUPAC/Chemical Name
L-Leucine, N2-acetyl-N6-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-L-lysyl-L-prolyl-N2-methyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-3-methyl-L-valyl-
InChi Key
XFKZVGLQBLOEFL-MBVHLSHRSA-N
InChi Code
InChI=1S/C68H113N19O18/c1-42(2)36-49(65(104)105)79-61(100)57(68(4,5)6)80-58(97)48(37-44-19-21-45(89)22-20-44)78-60(99)51-17-12-26-86(51)63(102)47(15-10-24-74-66(69)70)77-59(98)50(16-11-25-75-67(71)72)81(7)64(103)52-18-13-27-87(52)62(101)46(76-43(3)88)14-8-9-23-73-53(90)38-82-28-30-83(39-54(91)92)32-34-85(41-56(95)96)35-33-84(31-29-82)40-55(93)94/h19-22,42,46-52,57,89H,8-18,23-41H2,1-7H3,(H,73,90)(H,76,88)(H,77,98)(H,78,99)(H,79,100)(H,80,97)(H,91,92)(H,93,94)(H,95,96)(H,104,105)(H4,69,70,74)(H4,71,72,75)/t46-,47-,48-,49-,50-,51-,52-,57+/m0/s1
SMILES Code
CC(N[C@@H](CCCCNC(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O)=O)C(N2[C@@H](CCC2)C(N(C)[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](C(C)(C)C)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
To be determined
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Neurotensin receptor 1 (NTSR1) is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Specific noninvasive positron-emission tomography (PET) imaging probes may improve the diagnostic accuracy and the monitoring of therapy for patients with PDAC.

Preparing Stock Solutions

The following data is based on the product molecular weight 1,484.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Wu W, Yu F, Zhang P, Bu T, Fu J, Ai S, You Q, Shi L, Shao G, Wang F, Hodolic M, Guo H. 68Ga-DOTA-NT-20.3 Neurotensin Receptor 1 PET Imaging as a Surrogate for Neuroendocrine Differentiation of Prostate Cancer. J Nucl Med. 2022 Sep;63(9):1394-1400. doi: 10.2967/jnumed.121.263132. Epub 2022 Feb 17. PMID: 35177423; PMCID: PMC9454456. 2. Prignon A, Provost C, Alshoukr F, Wendum D, Couvelard A, Barbet J, Forgez P, Talbot JN, Gruaz-Guyon A. Preclinical Evaluation of 68Ga-DOTA-NT-20.3: A Promising PET Imaging Probe To Discriminate Human Pancreatic Ductal Adenocarcinoma from Pancreatitis. Mol Pharm. 2019 Jun 3;16(6):2776-2784. doi: 10.1021/acs.molpharmaceut.9b00283. Epub 2019 May 3. PMID: 31013092.

View History

A28695B

A28695B