MedKoo Cat#: 205839 | Name: GDC-0349
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GDC-0349 is a small molecule anticaner drug candidate, being developed by Genentech. As of July 2012, Genentech has filed phase I trial of GDC-0349 for evaluating the Safety and Tolerability of GDC-0349 in Patients With Locally Advanced or Metastatic Solid Tumors or Non Hodgkin's Lymphoma.

Chemical Structure

GDC-0349
GDC-0349
CAS#1207360-89-1

Theoretical Analysis

MedKoo Cat#: 205839

Name: GDC-0349

CAS#: 1207360-89-1

Chemical Formula: C24H32N6O3

Exact Mass: 452.2536

Molecular Weight: 452.55

Elemental Analysis: C, 63.70; H, 7.13; N, 18.57; O, 10.61

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 2 Weeks
10mg USD 450.00 2 Weeks
25mg USD 950.00 2 Weeks
50mg USD 1,450.00 2 Weeks
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Related CAS #
No Data
Synonym
GDC0349; GDC 0349; GDC-0349; RG7603; RG 7603; RG-7603
IUPAC/Chemical Name
(S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea
InChi Key
RGJOJUGRHPQXGF-INIZCTEOSA-N
InChi Code
InChI=1S/C24H32N6O3/c1-3-25-24(31)26-18-6-4-17(5-7-18)22-27-21-12-29(19-14-33-15-19)9-8-20(21)23(28-22)30-10-11-32-13-16(30)2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,25,26,31)/t16-/m0/s1
SMILES Code
O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C4C(CN(C5COC5)CC4)=N2)C=C1)NCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>5 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
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Preparing Stock Solutions

The following data is based on the product molecular weight 452.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL