MedKoo Cat#: 123925 | Name: CDK8-IN-12
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CDK8-IN-12 is an orally active, potent CDK8 inhibitor.

Chemical Structure

CDK8-IN-12
CDK8-IN-12
CAS#2613307-67-6

Theoretical Analysis

MedKoo Cat#: 123925

Name: CDK8-IN-12

CAS#: 2613307-67-6

Chemical Formula: C21H20ClN3O2

Exact Mass: 381.1244

Molecular Weight: 381.86

Elemental Analysis: C, 66.05; H, 5.28; Cl, 9.28; N, 11.00; O, 8.38

Price and Availability

Size Price Availability Quantity
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 3,450.00 2 Weeks
1g USD 4,850.00 2 Weeks
2g USD 6,850.00 2 Weeks
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Related CAS #
No Data
Synonym
CDK8-IN-12; CDK8-IN 12; CDK8 IN-12; CDK8 IN 12
IUPAC/Chemical Name
8-(3-(benzofuran-2-yl)-5-chloropyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
InChi Key
ILMHDRGZABQLEW-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H20ClN3O2/c22-16-13-23-12-15(18-11-14-3-1-2-4-17(14)27-18)19(16)25-9-6-21(7-10-25)5-8-24-20(21)26/h1-4,11-13H,5-10H2,(H,24,26)
SMILES Code
O=C1NCCC12CCN(C3=C(C4=CC5=CC=CC=C5O4)C=NC=C3Cl)CC2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 381.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Yu M, Teo T, Yang Y, Li M, Long Y, Philip S, Noll B, Heinemann GK, Diab S, Eldi P, Mekonnen L, Anshabo AT, Rahaman MH, Milne R, Hayball JD, Wang S. Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation. Eur J Med Chem. 2021 Mar 15;214:113248. doi: 10.1016/j.ejmech.2021.113248. Epub 2021 Feb 3. PMID: 33571827.