TBE56 is actually a potent and selective BACH1 degrader. BACH1 (BTB and CNC Homology 1) is a transcriptional repressor implicated in cancer metastasis and oxidative stress response. TBE56 promotes proteasomal degradation of BACH1, leading to upregulation of its target genes like HMOX1 (heme oxygenase 1). In cellular studies, TBE56 induces robust BACH1 degradation in human cancer cell lines (e.g., MDA-MB-231) with a DC₅₀ (degradation concentration 50%) in the low nanomolar range (~20–50 nM) and significantly increases HMOX1 mRNA levels by more than 10-fold within 6 hours. In xenograft models, TBE56 reduces BACH1 protein levels in tumors and suppresses lung metastasis without notable toxicity.
MedKoo Cat#: 130594
Name: TBE56
CAS#: 1459836-79-3
Chemical Formula: C37H43N5O6S
Exact Mass: 685.2934
Molecular Weight: 685.84
Elemental Analysis: C, 64.80; H, 6.32; N, 10.21; O, 14.00; S, 4.67
The following data is based on the product molecular weight 685.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
