MedKoo Cat#: 130589 | Name: PNT sensor PS3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PNT sensor PS3 is a novel sensitive and selective fluorescent peroxynitrite (PNT) sensor. It accumulates in the endoplasmic reticulum of cell membranes and is oxidatively cleaved by PNT to provide a fluorescent product.

Chemical Structure

PNT sensor PS3
PNT sensor PS3
CAS#PNT sensor PS3

Theoretical Analysis

MedKoo Cat#: 130589

Name: PNT sensor PS3

CAS#: PNT sensor PS3

Chemical Formula: C29H23F2NO3

Exact Mass: 471.1646

Molecular Weight: 471.50

Elemental Analysis: C, 73.87; H, 4.92; F, 8.06; N, 2.97; O, 10.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PS3, PNT-PS3, PNT PS3
IUPAC/Chemical Name
2,7-Difluoro-6-((4-hydroxy-3,5-dimethylphenyl)(methyl)amino)-9-(o-tolyl)-3H-xanthen-3-one
InChi Key
HDHHSYXLPWPUKY-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H23F2NO3/c1-15-7-5-6-8-19(15)28-20-11-22(30)24(32(4)18-9-16(2)29(34)17(3)10-18)13-26(20)35-27-14-25(33)23(31)12-21(27)28/h5-14,34H,1-4H3
SMILES Code
O=C1C(F)=CC2=C(C3=CC=CC=C3C)C4=C(C=C(N(C5=CC(C)=C(O)C(C)=C5)C)C(F)=C4)OC2=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 471.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Carlson EJ, Savardekar H, Hu X, Lapurga G, Johnson C, Sun SH, Carson WE, Peterson BR. Fluorescent Detection of Peroxynitrite Produced by Myeloid-Derived Suppressor Cells in Cancer and Inhibition by Dasatinib. ACS Pharmacol Transl Sci. 2023 May 2;6(5):738-747. doi: 10.1021/acsptsci.3c00014. PMID: 37200815; PMCID: PMC10186365. 2. Rane D, Carlson EJ, Yin Y, Peterson BR. Fluorescent detection of peroxynitrite during antibody-dependent cellular phagocytosis. Methods Enzymol. 2020;640:1-35. doi: 10.1016/bs.mie.2020.04.001. Epub 2020 May 18. PMID: 32560793; PMCID: PMC7473247.