Ac-His-pCF3-d-Phe-Arg-Aia | CAS# | hMC4R Agonist

MedKoo Cat#: 130564 | Name: Ac-His-pCF3-d-Phe-Arg-Aia

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ac-His-pCF3-d-Phe-Arg-Aia is a novel, potent, and selective agonist of human melanocortin 4 receptor (hMC4R) with an EC50 of 4.1 nM at hMC4R and at least ninefold selectivity.

Chemical Structure

Ac-His-pCF3-d-Phe-Arg-Aia

CAS#Ac-His-pCF3-d-Phe-Arg-Aia

Theoretical Analysis

MedKoo Cat#: 130564

Name: Ac-His-pCF3-d-Phe-Arg-Aia

CAS#: Ac-His-pCF3-d-Phe-Arg-Aia

Chemical Formula: C36H42F3N11O5

Exact Mass: 765.3322

Molecular Weight: 765.80

Elemental Analysis: C, 56.46; H, 5.53; F, 7.44; N, 20.12; O, 10.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Ac His pCF3 d Phe Arg Aia

IUPAC/Chemical Name

(S)-2-((R)-2-((S)-2-Acetamido-3-(1H-imidazol-4-yl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanamido)-5-guanidino-N-((S)-3-oxo-1,2,3,4,5,10-hexahydroazepino[3,4-b]indol-4-yl)pentanamide

InChi Key

YKAWDEHFCQNJSK-CRNKYVSFSA-N

InChi Code

InChI=1S/C35H43N11O5/c1-20(47)42-28(15-22-17-38-19-41-22)34(51)45-27(14-21-8-3-2-4-9-21)33(50)44-26(12-7-13-39-35(36)37)32(49)46-29-16-24-23-10-5-6-11-25(23)43-30(24)18-40-31(29)48/h2-6,8-11,17,19,26-29,43H,7,12-16,18H2,1H3,(H,38,41)(H,40,48)(H,42,47)(H,44,50)(H,45,51)(H,46,49)(H4,36,37,39)/t26-,27+,28-,29-/m0/s1

SMILES Code

O=C(N[C@H]1CC2=C(CNC1=O)NC3=C2C=CC=C3)[C@@H](NC([C@H](NC([C@@H](NC(C)=O)CC4=CNC=N4)=O)CC5=CC=CC=C5)=O)CCCNC(N)=N

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 765.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Zhou Y, Mowlazadeh Haghighi S, Sawyer JR, Hruby VJ, Cai M. Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH2 Lead to Potent and Selective Agonists at hMC1R and hMC4R. J Med Chem. 2023 May 25;66(10):6715-6724. doi: 10.1021/acs.jmedchem.2c01794. Epub 2023 May 3. PMID: 37133411.