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MedKoo Cat#: 130563 | Name: Ac-His-d-Phe-Arg-Aia

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ac-His-d-Phe-Arg-Aia is a novel, potent, and selective agonist of human melanocortin 1 receptor (hMC1R). It has an EC50 of 11.2 nM for hMC1R and at least 15-fold selectivity compared to other MCR subtypes.

Chemical Structure

Ac-His-d-Phe-Arg-Aia
Ac-His-d-Phe-Arg-Aia
CAS#Ac-His-d-Phe-Arg-Aia

Theoretical Analysis

MedKoo Cat#: 130563

Name: Ac-His-d-Phe-Arg-Aia

CAS#: Ac-His-d-Phe-Arg-Aia

Chemical Formula: C35H43N11O5

Exact Mass: 697.3449

Molecular Weight: 697.80

Elemental Analysis: C, 60.24; H, 6.21; N, 22.08; O, 11.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ac His d Phe Arg Aia
IUPAC/Chemical Name
(S)-2-((R)-2-((S)-2-Acetamido-3-(1H-imidazol-4-yl)propanamido)-3-phenylpropanamido)-5-guanidino-N-((S)-3-oxo-1,2,3,4,5,10-hexahydroazepino[3,4-b]indol-4-yl)pentanamide
InChi Key
YKAWDEHFCQNJSK-CRNKYVSFSA-N
InChi Code
InChI=1S/C35H43N11O5/c1-20(47)42-28(15-22-17-38-19-41-22)34(51)45-27(14-21-8-3-2-4-9-21)33(50)44-26(12-7-13-39-35(36)37)32(49)46-29-16-24-23-10-5-6-11-25(23)43-30(24)18-40-31(29)48/h2-6,8-11,17,19,26-29,43H,7,12-16,18H2,1H3,(H,38,41)(H,40,48)(H,42,47)(H,44,50)(H,45,51)(H,46,49)(H4,36,37,39)/t26-,27+,28-,29-/m0/s1
SMILES Code
O=C(N[C@H]1CC2=C(CNC1=O)NC3=C2C=CC=C3)[C@@H](NC([C@H](NC([C@@H](NC(C)=O)CC4=CNC=N4)=O)CC5=CC=CC=C5)=O)CCCNC(N)=N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 697.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zhou Y, Mowlazadeh Haghighi S, Sawyer JR, Hruby VJ, Cai M. Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH2 Lead to Potent and Selective Agonists at hMC1R and hMC4R. J Med Chem. 2023 May 25;66(10):6715-6724. doi: 10.1021/acs.jmedchem.2c01794. Epub 2023 May 3. PMID: 37133411.

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