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MedKoo Cat#: 130556 | Name: TH7299

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TH7299 is a novel, potent MTHFD1/D2/D2L inhibitor. It is more potent towards MTHFD1 and MTHFD2L than MTHFD2.

Chemical Structure

TH7299
TH7299
CAS#1415648-20-2

Theoretical Analysis

MedKoo Cat#: 130556

Name: TH7299

CAS#: 1415648-20-2

Chemical Formula: C18H20N6O7

Exact Mass: 432.1393

Molecular Weight: 432.39

Elemental Analysis: C, 50.00; H, 4.66; N, 19.44; O, 25.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TH 7299, TH-7299
IUPAC/Chemical Name
(4-(3-(4,6-Diamino-2-oxo-1,2-dihydropyridin-3-yl)ureido)benzoyl)-L-glutamic acid
InChi Key
XYBHHWPTCKDMPA-NSHDSACASA-N
InChi Code
InChI=1S/C18H20N6O7/c19-10-7-12(20)23-16(28)14(10)24-18(31)21-9-3-1-8(2-4-9)15(27)22-11(17(29)30)5-6-13(25)26/h1-4,7,11H,5-6H2,(H,22,27)(H,25,26)(H,29,30)(H2,21,24,31)(H5,19,20,23,28)/t11-/m0/s1
SMILES Code
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NC(NC2=C(N)C=C(N)NC2=O)=O)C=C1)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 432.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Scaletti ER, Gustafsson Westergren R, Andersson Y, Wiita E, Henriksson M, Homan EJ, Jemth AS, Helleday T, Stenmark P. The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors. ChemMedChem. 2022 Sep 16;17(18):e202200274. doi: 10.1002/cmdc.202200274. Epub 2022 Jul 6. PMID: 35712863; PMCID: PMC9796130.