Synonym
GIF 0726 r, GIF-0726 r, GIF 0726-r, GIF-0726r, GIF 0726 r, GIF0726r
IUPAC/Chemical Name
3-(4-(Dimethylamino)benzyl)indolin-2-one
InChi Key
WEKJKJMTUWIENI-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H18N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-10,15H,11H2,1-2H3,(H,18,20)
SMILES Code
O=C1NC2=C(C=CC=C2)C1CC3=CC=C(N(C)C)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
266.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Takahashi M, Hamamoto A, Oh-Hashi K, Takemori H, Furuta K, Hirata Y. Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities. ACS Chem Neurosci. 2023 May 17;14(10):1826-1833. doi: 10.1021/acschemneuro.3c00042. Epub 2023 Apr 27. PMID: 37104649.
2. Hasegawa Y, Motoyama M, Hamamoto A, Kimura S, Kamatari YO, Kamishina H, Oh-Hashi K, Furuta K, Hirata Y. Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones. ACS Chem Neurosci. 2022 Apr 6;13(7):1055-1064. doi: 10.1021/acschemneuro.2c00064. Epub 2022 Mar 16. PMID: 35294164.
3. Hirata Y, Tsunekawa Y, Takahashi M, Oh-Hashi K, Kawaguchi K, Hayazaki M, Watanabe M, Koga KI, Hattori Y, Takemori H, Furuta K. Identification of novel neuroprotective N,N-dimethylaniline derivatives that prevent oxytosis/ferroptosis and localize to late endosomes and lysosomes. Free Radic Biol Med. 2021 Oct;174:225-235. doi: 10.1016/j.freeradbiomed.2021.08.015. Epub 2021 Aug 15. PMID: 34407426.
4. Hirata Y, Ito Y, Takashima M, Yagyu K, Oh-Hashi K, Suzuki H, Ono K, Furuta K, Sawada M. Novel Oxindole-Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection. ACS Chem Neurosci. 2020 Jan 2;11(1):76-85. doi: 10.1021/acschemneuro.9b00619. Epub 2019 Dec 18. PMID: 31799835.
5. Hirata Y, Yamada C, Ito Y, Yamamoto S, Nagase H, Oh-Hashi K, Kiuchi K, Suzuki H, Sawada M, Furuta K. Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells. Neuropharmacology. 2018 Jun;135:242-252. doi: 10.1016/j.neuropharm.2018.03.015. Epub 2018 Mar 15. PMID: 29551691.
