C1s inhibitor (R)-8 | CAS# | C1s inhibitor

MedKoo Cat#: 130545 | Name: C1s inhibitor (R)-8

Description:

WARNING: This product is for research use only, not for human or veterinary use.

C1s inhibitor (R)-8 is a novel, potent, selective, orally available, and brain-penetrable C1s inhibitor for modulation of the complement pathway.

Chemical Structure

C1s inhibitor (R)-8

CAS#C1s inhibitor (R)-8

Theoretical Analysis

MedKoo Cat#: 130545

Name: C1s inhibitor (R)-8

CAS#: C1s inhibitor (R)-8

Chemical Formula: C22H20F2N6O

Exact Mass: 422.1667

Molecular Weight: 422.44

Elemental Analysis: C, 62.55; H, 4.77; F, 8.99; N, 19.89; O, 3.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

C1s inhibitor R-8, C1s inhibitor (R)8,C1s inhibitor R-8, C1s In R-8, C1s In (R)8, C1s In R-8, C1s inhibitor (R)-8

IUPAC/Chemical Name

(R)-8-Fluoro-6-(4-(3-fluorophenyl)-3-(5-methylisoxazol-3-yl)piperazin-1-yl)phthalazin-1-amine

InChi Key

HXAFDSAENALNGM-HXUWFJFHSA-N

InChi Code

InChI=1S/C22H20F2N6O/c1-13-7-19(28-31-13)20-12-29(5-6-30(20)16-4-2-3-15(23)9-16)17-8-14-11-26-27-22(25)21(14)18(24)10-17/h2-4,7-11,20H,5-6,12H2,1H3,(H2,25,27)/t20-/m1/s1

SMILES Code

NC1=NN=CC2=C1C(F)=CC(N3C[C@H](C4=NOC(C)=C4)N(C5=CC=CC(F)=C5)CC3)=C2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 422.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Ikeda Z, Kamei T, Sasaki Y, Reynolds M, Sakai N, Yoshikawa M, Tawada M, Morishita N, Dougan DR, Chen CH, Levin I, Zou H, Kuno M, Arimura N, Kikukawa Y, Kondo M, Tohyama K, Sato K. Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway. J Med Chem. 2023 May 11;66(9):6354-6371. doi: 10.1021/acs.jmedchem.3c00348. Epub 2023 Apr 25. PMID: 37120845; PMCID: PMC10184130.