MedKoo Cat#: 130539 | Name: AT2R inhibitor A-174

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AT2R inhibitor A-174 is a novel inhibitor of the angiotensin II type 2 receptor (AT2R). It is being investigated as a non-opioid approach to treating neuropathic pain.

Chemical Structure

AT2R inhibitor A-174
AT2R inhibitor A-174
CAS#AT2R inhibitor A-174

Theoretical Analysis

MedKoo Cat#: 130539

Name: AT2R inhibitor A-174

CAS#: AT2R inhibitor A-174

Chemical Formula: C21H27FN8

Exact Mass: 410.2343

Molecular Weight: 410.50

Elemental Analysis: C, 61.44; H, 6.63; F, 4.63; N, 27.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
AT2R In A-174, AT2R inhibitor A174, AT2R inhibitor A 174, AT2R In A174, AT2R-In-A-174, AT2RInA174
IUPAC/Chemical Name
(S)-3-((4-(3-Fluoro-5-isobutyl-2-(2H-tetrazol-5-yl)phenyl)-2-methylpiperazin-1-yl)methyl)pyridazine
InChi Key
BHRGLVGWNMTDFE-HNNXBMFYSA-N
InChi Code
InChI=1S/C21H27FN8/c1-14(2)9-16-10-18(22)20(21-25-27-28-26-21)19(11-16)30-8-7-29(15(3)12-30)13-17-5-4-6-23-24-17/h4-6,10-11,14-15H,7-9,12-13H2,1-3H3,(H,25,26,27,28)/t15-/m0/s1
SMILES Code
C[C@@H]1N(CC2=NN=CC=C2)CCN(C3=CC(CC(C)C)=CC(F)=C3C4=NNN=N4)C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 410.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Balogh M, Aguilar C, Nguyen NT, Shepherd AJ. Angiotensin receptors and neuropathic pain. Pain Rep. 2021 Mar 9;6(1):e869. doi: 10.1097/PR9.0000000000000869. PMID: 33981922; PMCID: PMC8108581.