MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 130534 | Name: SQ3370

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SQ3370 is the first Click Activated Protodrugs Against Cancer (CAPAC) doxorubicin (Dox) protodrug that uses click chemistry to activate drug with SQL70 directly at tumor sites, maximizing therapeutic exposure.

Chemical Structure

SQ3370
SQ3370
CAS#SQ3370

Theoretical Analysis

MedKoo Cat#: 130534

Name: SQ3370

CAS#: SQ3370

Chemical Formula: C40H45N2NaO16

Exact Mass: 832.2667

Molecular Weight: 832.79

Elemental Analysis: C, 57.69; H, 5.45; N, 3.36; Na, 2.76; O, 30.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SQ 3370, SQ-3370
IUPAC/Chemical Name
Sodium ((1R,3R,E)-3-((((2S,3R,4S,6R)-3-hydroxy-2-methyl-6-(((1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)carbamoyl)oxy)-1-methylcyclooct-4-ene-1-carbonyl)glycinat
InChi Key
NABCSHBAXNCYOH-ZQMGWUGESA-M
InChi Code
InChI=1S/C40H46N2O16.Na/c1-18-32(47)22(42-38(53)57-19-8-5-4-6-11-39(2,13-19)37(52)41-16-26(45)46)12-27(56-18)58-24-15-40(54,25(44)17-43)14-21-29(24)36(51)31-30(34(21)49)33(48)20-9-7-10-23(55-3)28(20)35(31)50;/h5,7-10,18-19,22,24,27,32,43,47,49,51,54H,4,6,11-17H2,1-3H3,(H,41,52)(H,42,53)(H,45,46);/q;+1/p-1/b8-5+;/t18-,19-,22-,24-,27-,32-,39+,40-;/m0./s1
SMILES Code
O=C([O-])CNC([C@@]1(C)C[C@@H](OC(N[C@@H]2[C@@H](O)[C@H](C)O[C@@H](O[C@H]3C[C@@](C(CO)=O)(O)CC4=C(O)C5=C(C(C6=C(OC)C=CC=C6C5=O)=O)C(O)=C34)C2)=O)/C=C/CCC1)=O.[Na+]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 832.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Srinivasan S, Yee NA, Zakharian M, Alečković M, Mahmoodi A, Nguyen TH, Mejía Oneto JM. SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species. bioRxiv [Preprint]. 2023 Mar 29:2023.03.28.534654. doi: 10.1101/2023.03.28.534654. PMID: 37034617; PMCID: PMC10081183. 2. Wu K, Yee NA, Srinivasan S, Mahmoodi A, Zakharian M, Mejia Oneto JM, Royzen M. Click activated protodrugs against cancer increase the therapeutic potential of chemotherapy through local capture and activation. Chem Sci. 2021 Jan 5;12(4):1259-1271. doi: 10.1039/d0sc06099b. Erratum in: Chem Sci. 2021 May 21;12(21):7583. PMID: 34163888; PMCID: PMC8179178. 3. Srinivasan S, Yee NA, Wu K, Zakharian M, Mahmoodi A, Royzen M, Oneto JMM. SQ3370 Activates Cytotoxic Drug via Click Chemistry at Tumor and Elicits Sustained Responses in Injected & Non-injected Lesions. Adv Ther (Weinh). 2021 Mar;4(3):2000243. doi: 10.1002/adtp.202000243. Epub 2021 Jan 20. PMID: 33869738; PMCID: PMC8049173.