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MedKoo Cat#: 130533 | Name: MMV008416

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MMV008416 is an inhibitor of methionine aminopeptidases, type I (MetAp1) from Rickettsia prowazekii (RpMetAp1).

Chemical Structure

MMV008416
CAS#MMV008416

Theoretical Analysis

MedKoo Cat#: 130533

Name: MMV008416

CAS#: MMV008416

Chemical Formula: C15H20N2

Exact Mass: 228.1626

Molecular Weight: 228.34

Elemental Analysis: C, 78.90; H, 8.83; N, 12.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MMV 008416, MMV-008416, GNF-Pf-3651, MLS000080101, SMR000036351, NSC766427, STK007737, AKOS005375852, NSC-766427
IUPAC/Chemical Name
3-Ethyl-1-methyl-2-propylquinolin-4-imine
InChi Key
JAPBALWUJAIERZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H20N2/c1-4-8-13-11(5-2)15(16)12-9-6-7-10-14(12)17(13)3/h6-7,9-10,16H,4-5,8H2,1-3H3
SMILES Code
CCC1=C(CCC)N(C)C2=CC=CC=C2C1=N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 228.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Sharma I, Chen C, Daraji D, Horn JR, Hagen TJ. Novel inhibitors of Rickettsia prowazekii methionine aminopeptidase from the Malaria Box. Bioorg Med Chem Lett. 2023 May 1;87:129281. doi: 10.1016/j.bmcl.2023.129281. Epub 2023 Apr 7. PMID: 37031729. 2. Chirawurah JD, Ansah F, Nyarko PB, Duodu S, Aniweh Y, Awandare GA. Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates. Int J Parasitol Drugs Drug Resist. 2017 Dec;7(3):399-406. doi: 10.1016/j.ijpddr.2017.10.005. Epub 2017 Oct 16. PMID: 29128848; PMCID: PMC5683671. 3. Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, Groessl T, Kato N, Lee MC, McNamara CW, Fidock DA, Nagle A, Nam TG, Richmond W, Roland J, Rottmann M, Zhou B, Froissard P, Glynne RJ, Mazier D, Sattabongkot J, Schultz PG, Tuntland T, Walker JR, Zhou Y, Chatterjee A, Diagana TT, Winzeler EA. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011 Dec 9;334(6061):1372-7. doi: 10.1126/science.1211936. Epub 2011 Nov 17. PMID: 22096101; PMCID: PMC3473092.