Synonym
WS 635, WS635, SHP2 inhibitor WS-635, SHP2 In WS-635
IUPAC/Chemical Name
Ethyl (E)-5-(furan-2-yl)-2-(furan-2-ylmethylene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate
InChi Key
CZFMMKNXNCUEMU-GXDHUFHOSA-N
InChi Code
InChI=1S/C19H16N2O5S/c1-3-24-18(23)15-11(2)20-19-21(16(15)13-7-5-9-26-13)17(22)14(27-19)10-12-6-4-8-25-12/h4-10,16H,3H2,1-2H3/b14-10+
SMILES Code
O=C(C1=C(C)N=C(S/C(C2=O)=C/C3=CC=CO3)N2C1C4=CC=CO4)OCC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
384.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Song Y, Zhao M, Wu Y, Yu B, Liu HM. A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors. Acta Pharm Sin B. 2021 Mar;11(3):750-762. doi: 10.1016/j.apsb.2020.10.021. Epub 2020 Oct 31. PMID: 33777680; PMCID: PMC7982506.
2. Lin J, Shen F, Lu J, Liang F, Zhang Y, Xie Z, Dong Y. WS635 Attenuates the Anesthesia/Surgery-Induced Cognitive Impairment in Mice. Front Aging Neurosci. 2021 Jul 21;13:688587. doi: 10.3389/fnagi.2021.688587. PMID: 34366827; PMCID: PMC8335586.
3. Lu J, Liang F, Bai P, Liu C, Xu M, Sun Z, Tian W, Dong Y, Zhang Y, Quan Q, Khatri A, Shen Y, Marcantonio E, Crosby G, Culley DJ, Wang C, Yang G, Xie Z. Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice. Alzheimers Dement. 2023 May 30. doi: 10.1002/alz.13118. Epub ahead of print. PMID: 37249148.
