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MedKoo Cat#: 130521 | Name: DK2403

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DK2403 is a novel, highly potent, and selective covalent inhibitor of MAP2K7 (also known as MEK7 and MKK7).

Chemical Structure

DK2403
DK2403
CAS#2902651-64-1

Theoretical Analysis

MedKoo Cat#: 130521

Name: DK2403

CAS#: 2902651-64-1

Chemical Formula: C19H17ClN4O2

Exact Mass: 368.1040

Molecular Weight: 368.82

Elemental Analysis: C, 61.88; H, 4.65; Cl, 9.61; N, 15.19; O, 8.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DK 2403, DK-2403, MAP2K7 Inhibitor DK2403, MEK7 Inhibitor DK2403, MKK7 Inhibitor DK2403, MAP2K7-In-DK2403, MEK7-In-DK2403, MKK7-In-DK2403, MAP2K7 In DK2403, MEK7 In DK2403, MKK7 In DK2403
IUPAC/Chemical Name
N-(3-((6-(Benzylamino)pyrimidin-4-yl)oxy)phenyl)-2-chloroacetamide
InChi Key
SWAPCFYOLJWGBA-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H17ClN4O2/c20-11-18(25)24-15-7-4-8-16(9-15)26-19-10-17(22-13-23-19)21-12-14-5-2-1-3-6-14/h1-10,13H,11-12H2,(H,24,25)(H,21,22,23)
SMILES Code
O=C(NC1=CC=CC(OC2=NC=NC(NCC3=CC=CC=C3)=C2)=C1)CCl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 368.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Kim DR, Orr MJ, Kwong AJ, Deibler KK, Munshi HH, Bridges CS, Chen TJ, Zhang X, Lacorazza HD, Scheidt KA. Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett. 2023 Apr 17;14(5):606-613. doi: 10.1021/acsmedchemlett.3c00029. PMID: 37197477; PMCID: PMC10184151.