PF-04254644 | inhibitor | receptor tyrosine kinase c-Met

MedKoo Cat#: 123777 | Name: PF-04254644

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-04254644 is an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family in inhibition leading to myocardial degeneration in rats.

Chemical Structure

PF-04254644

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 123777

Name: PF-04254644

CAS#: N/A

Chemical Formula: C20H17N7

Exact Mass: 355.1500

Molecular Weight: 355.41

Elemental Analysis: C, 67.59; H, 4.82; N, 27.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CHEMBL2431819; PF-04254644; SCHEMBL4197071; PF04254644; PF 04254644

IUPAC/Chemical Name

6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline

InChi Key

VQYHPUHKYSSEOB-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H17N7/c1-13(14-5-6-17-15(10-14)4-3-9-21-17)20-24-23-19-8-7-18(25-27(19)20)16-11-22-26(2)12-16/h3-13H,1-2H3

SMILES Code

CC(C1=CC2=C(C=C1)N=CC=C2)C3=NN=C4N3N=C(C=C4)C5=CN(N=C5)C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 355.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hu W, Hirakawa B, Jessen B, Lee M, Aguirre S. A tyrosine kinase inhibitor- induced myocardial degeneration in rats through off-target phosphodiesterase inhibition. J Appl Toxicol. 2012 Dec;32(12):1008-20. doi: 10.1002/jat.2801. Epub 2012 Aug 31. PMID: 22936366. 2: Aguirre SA, Heyen JR, Collette W 3rd, Bobrowski W, Blasi ER. Cardiovascular effects in rats following exposure to a receptor tyrosine kinase inhibitor. Toxicol Pathol. 2010 Apr;38(3):416-28. doi: 10.1177/0192623310364027. Epub 2010 Mar 15. PMID: 20231546. 3: Cui JJ, Shen H, Tran-Dubé M, Nambu M, McTigue M, Grodsky N, Ryan K, Yamazaki S, Aguirre S, Parker M, Li Q, Zou H, Christensen J. Lessons from (S)-6-(1-(6-(1- methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial degeneration in rats. J Med Chem. 2013 Sep 12;56(17):6651-65. doi: 10.1021/jm400926x. Epub 2013 Aug 29. PMID: 23944843.