Synonym
FABP3 inhibitor MF 1, FABP3 inhibitor MF-1, FABP3-In-MF1, FABP3-In-MF-1, FABP3 In MF1, Fatty Acid Binding Protein 3 Inhibitor 3, Fatty Acid Binding Protein Inhibitor-3, 4-(2-(5-(2-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)phenoxy)butanoic acid
IUPAC/Chemical Name
4-(2-(5-(2-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)phenoxy)butanoic acid
InChi Key
ZFPJARIXQWTDSX-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H21ClN2O3/c26-21-13-6-4-11-19(21)23-17-22(27-28(23)18-9-2-1-3-10-18)20-12-5-7-14-24(20)31-16-8-15-25(29)30/h1-7,9-14,17H,8,15-16H2,(H,29,30)
SMILES Code
O=C(O)CCCOC1=CC=CC=C1C2=NN(C3=CC=CC=C3)C(C4=CC=CC=C4Cl)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
432.90
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Jia W, Kawahata I, Cheng A, Sasaki T, Sasaoka T, Fukunaga K. Amelioration of Nicotine-Induced Conditioned Place Preference Behaviors in Mice by an FABP3 Inhibitor. Int J Mol Sci. 2023 Apr 2;24(7):6644. doi: 10.3390/ijms24076644. PMID: 37047614; PMCID: PMC10095245.
2. Yabuki Y, Matsuo K, Kawahata I, Fukui N, Mizobata T, Kawata Y, Owada Y, Shioda N, Fukunaga K. Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain. Int J Mol Sci. 2020 Mar 23;21(6):2230. doi: 10.3390/ijms21062230. PMID: 32210174; PMCID: PMC7139546.
3. Haga H, Yamada R, Izumi H, Shinoda Y, Kawahata I, Miyachi H, Fukunaga K. Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice. Pharmacol Biochem Behav. 2020 Apr;191:172891. doi: 10.1016/j.pbb.2020.172891. Epub 2020 Feb 29. PMID: 32126223.
