JAK/HDAC inhibitor 30 | CAS# | JAK and HDAC inhibitor

MedKoo Cat#: 130500 | Name: JAK/HDAC inhibitor 30

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JAK/HDAC inhibitor 30 is a novel dual JAK/HDAC inhibitor. It potentially inhibits HDAC3/6 and JAK1/2 at the nanomolar level and is selective for JAK2. It presents antiproliferative activity in both hematological malignancies and solid cancers.

Chemical Structure

JAK/HDAC inhibitor 30

CAS#JAK/HDAC inhibitor 30

Theoretical Analysis

MedKoo Cat#: 130500

Name: JAK/HDAC inhibitor 30

CAS#: JAK/HDAC inhibitor 30

Chemical Formula: C28H37FN6O5S

Exact Mass: 588.2530

Molecular Weight: 588.70

Elemental Analysis: C, 57.13; H, 6.34; F, 3.23; N, 14.28; O, 13.59; S, 5.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JAK/HDAC inhibitor-30, JAK/HDAC In 30, JAK/HDAC-In-30, JAK/HDAC-In 30

IUPAC/Chemical Name

7-(4-((4-((3-(N-(tert-Butyl)sulfamoyl)phenyl)amino)-5-methylpyrimidin-2-yl)amino)-2-fluorophenoxy)-N-hydroxyheptanamide

InChi Key

XQYXAGOVMRYFIS-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H37FN6O5S/c1-19-18-30-27(33-26(19)31-20-10-9-11-22(16-20)41(38,39)35-28(2,3)4)32-21-13-14-24(23(29)17-21)40-15-8-6-5-7-12-25(36)34-37/h9-11,13-14,16-18,35,37H,5-8,12,15H2,1-4H3,(H,34,36)(H2,30,31,32,33)

SMILES Code

FC1=CC(NC2=NC=C(C)C(NC3=CC=CC(S(NC(C)(C)C)(=O)=O)=C3)=N2)=CC=C1OCCCCCCC(NO)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 588.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Qiu Q, Chi F, Zhou D, Xie Z, Liu Y, Wu H, Yin Z, Shi W, Qian H. Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers. J Med Chem. 2023 Apr 27;66(8):5753-5773. doi: 10.1021/acs.jmedchem.3c00036. Epub 2023 Apr 14. PMID: 37057760.