GNS-1481 | CAS# 1903008-81-0 | EGFR kinase inhibitor

MedKoo Cat#: 130486 | Name: GNS-1481

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GNS-1481 is a novel EGFR kinase inhibitor, selectively targeting T790M mutant isoforms of EGFR.

Chemical Structure

GNS-1481

CAS#1903008-81-0

Theoretical Analysis

MedKoo Cat#: 130486

Name: GNS-1481

CAS#: 1903008-81-0

Chemical Formula: C27H34N8O3

Exact Mass: 518.2754

Molecular Weight: 518.62

Elemental Analysis: C, 62.53; H, 6.61; N, 21.61; O, 9.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GNS1481, GNS 1481, GNS - 1481

IUPAC/Chemical Name

N-{5-[4-(3-Cyclopropyl-4-dimethylaminomethyl-pyrazol-1-yl)-pyrimidin-2-ylamino]-4-methoxy-2-morpholin-4-yl-phenyl}-acrylamide

InChi Key

SEKXPOMGSBSXQJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H34N8O3/c1-5-25(36)29-20-14-21(23(37-4)15-22(20)34-10-12-38-13-11-34)30-27-28-9-8-24(31-27)35-17-19(16-33(2)3)26(32-35)18-6-7-18/h5,8-9,14-15,17-18H,1,6-7,10-13,16H2,2-4H3,(H,29,36)(H,28,30,31)

SMILES Code

C=CC(NC1=CC(NC2=NC=CC(N3C=C(CN(C)C)C(C4CC4)=N3)=N2)=C(OC)C=C1N5CCOCC5)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 518.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Rho JK, Lee IY, Choi YJ, Choi CM, Hur JY, Koh JS, Lee J, Suh BC, Song HJ, Salgaonkar P, Lee J, Lee J, Jung DS, Kim SY, Woo DC, Baek IJ, Lee JY, Ha CH, Sung YH, Kim JK, Kim WS, Song JS, Kim CH, Bivona TG, Lee JC. Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer. Cancer Res. 2017 Mar 1;77(5):1200-1211. doi: 10.1158/0008-5472.CAN-16-2432. Epub 2017 Jan 12. PMID: 28082405; PMCID: PMC5334209.