MedKoo Cat#: 556323 | Name: WAY-272077
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

WAY-272077 is a Sphingosine kinase (SphK1, SphK2) inhibitor.

Chemical Structure

WAY-272077
WAY-272077
CAS#1415662-57-5

Theoretical Analysis

MedKoo Cat#: 556323

Name: WAY-272077

CAS#: 1415662-57-5

Chemical Formula: C14H14N2O3S

Exact Mass: 290.0725

Molecular Weight: 290.34

Elemental Analysis: C, 57.92; H, 4.86; N, 9.65; O, 16.53; S, 11.04

Price and Availability

Size Price Availability Quantity
100mg USD 950.00 2 Weeks
200mg USD 1,450.00 2 Weeks
500mg USD 2,450.00 2 Weeks
1g USD 3,450.00 2 Weeks
2g USD 5,450.00 2 Weeks
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Related CAS #
No Data
Synonym
WAY-272077; WAY272077; WAY 272077; SphK1&2-IN-1;
IUPAC/Chemical Name
(2E)-3-(3,4-Dimethoxyphenyl)-N-2-thiazolyl-2-propenamide
InChi Key
SMRXKMFZQYOXSX-GQCTYLIASA-N
InChi Code
InChI=1S/C14H14N2O3S/c1-18-11-5-3-10(9-12(11)19-2)4-6-13(17)16-14-15-7-8-20-14/h3-9H,1-2H3,(H,15,16,17)/b6-4+
SMILES Code
O=C(NC1=NC=CS1)/C=C/C2=CC=C(OC)C(OC)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Sphingosine kinases (SphK1, SphK2) are main regulators of sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in numerous physiol. and pathophysiol. functions. SphKs are targets for novel anticancer and anti-inflammatory agents that can promote cell apoptosis and modulate autoimmune diseases.

Preparing Stock Solutions

The following data is based on the product molecular weight 290.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Vogt D, Weber J, Ihlefeld K, Brüggerhoff A, Proschak E, Stark H. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67. doi: 10.1016/j.bmc.2014.07.044. Epub 2014 Aug 6. PMID: 25150091. 2.Nong W, Zhao A, Wei J, Lin X, Wang L, Lin C. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511. doi: 10.1016/j.bmcl.2017.07.058. Epub 2017 Jul 22. PMID: 28844387.