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MedKoo Cat#: 123542 | Name: XZ424

Description:

WARNING: This product is for research use only, not for human or veterinary use.

XZ424 is a PROTAC targeting BCL-XL

Chemical Structure

XZ424
XZ424
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 123542

Name: XZ424

CAS#: N/A

Chemical Formula: C61H61FN12O11S2

Exact Mass: 1220.4000

Molecular Weight: 1221.35

Elemental Analysis: C, 59.99; H, 5.03; F, 1.56; N, 13.76; O, 14.41; S, 5.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
XZ424; XZ-424; XZ 424
IUPAC/Chemical Name
2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(3-(4-(4-(4-((2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)butanoyl)piperazin-1-yl)prop-1-yn-1-yl)-2-fluorophenoxy)propyl)thiazole-4-carboxylic acid
InChi Key
KDSYVLYKZZKENZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C61H61FN12O11S2/c62-44-34-38(17-19-48(44)85-30-7-15-50-54(59(81)82)66-61(87-50)72-25-21-39-9-3-10-41(43(39)36-72)55(77)67-60-64-45-12-1-2-14-49(45)86-60)8-5-23-70-26-28-71(29-27-70)52(76)16-6-24-73-35-40(68-69-73)37-84-33-32-83-31-22-63-46-13-4-11-42-53(46)58(80)74(57(42)79)47-18-20-51(75)65-56(47)78/h1-4,9-14,17,19,34-35,47,63H,6-7,15-16,18,20-33,36-37H2,(H,81,82)(H,64,67,77)(H,65,75,78)
SMILES Code
O=C1N(C(C2=C(NCCOCCOCC3=CN(N=N3)CCCC(N4CCN(CC4)CC#CC5=CC=C(OCCCC6=C(C(O)=O)N=C(N7CCC(C=CC=C8C(NC9=NC(C=CC=C%10)=C%10S9)=O)=C8C7)S6)C(F)=C5)=O)C=CC=C21)=O)C%11C(NC(CC%11)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,221.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Negi A, Voisin-Chiret AS. Strategies to Reduce the On-Target Platelet Toxicity of Bcl-xL Inhibitors: PROTACs, SNIPERs and Prodrug-Based Approaches. Chembiochem. 2022 Jun 20;23(12):e202100689. doi: 10.1002/cbic.202100689. Epub 2022 Mar 19. PMID: 35263486; PMCID: PMC9311450. 2: Zhang X , Thummuri D , He Y , Liu X , Zhang P , Zhou D , Zheng G . Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL. Chem Commun (Camb). 2019 Dec 5;55(98):14765-14768. doi: 10.1039/c9cc07217a. PMID: 31754664; PMCID: PMC7057339.