NR-6A | PROTAC targeting p38

MedKoo Cat#: 123538 | Name: NR-6A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NR-6A is a PROTAC targeting p38.

Chemical Structure

NR-6A

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 123538

Name: NR-6A

CAS#: N/A

Chemical Formula: C50H55BrF2N8O7

Exact Mass: 996.3300

Molecular Weight: 997.94

Elemental Analysis: C, 60.18; H, 5.56; Br, 8.01; F, 3.81; N, 11.23; O, 11.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NR-6A; NR6A; NR 6A

IUPAC/Chemical Name

3-(3-bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N-(4-(1-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexyl)amino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide

InChi Key

DYERNVOWSSIIQF-UHFFFAOYSA-N

InChi Code

InChI=1S/C50H55BrF2N8O7/c1-31-16-17-34(26-42(31)61-32(2)25-43(46(51)50(61)67)68-30-35-18-19-36(52)27-40(35)53)47(64)55-23-8-6-13-37-28-59(58-57-37)24-10-15-44(62)54-22-7-4-3-5-11-33-12-9-14-38-39(33)29-60(49(38)66)41-20-21-45(63)56-48(41)65/h9,12,14,16-19,25-28,41H,3-8,10-11,13,15,20-24,29-30H2,1-2H3,(H,54,62)(H,55,64)(H,56,63,65)

SMILES Code

FC1=CC=C(COC(C=C(C)N2C3=CC(C(NCCCCC4=CN(CCCC(NCCCCCCC5=C(CN(C6C(NC(CC6)=O)=O)C7=O)C7=CC=C5)=O)N=N4)=O)=CC=C3C)=C(Br)C2=O)C(F)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 997.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Harrell LJ, Mirrett S, Reller LB. Subcultures of BACTEC-positive but gram or acridine orange stain-negative NR 6A and 7A blood culture bottles are unnecessary. Diagn Microbiol Infect Dis. 1994 Nov;20(3):121-5. doi: 10.1016/0732-8893(94)90105-8. PMID: 7874878. 2: Courcol RJ, Durocher AV, Roussel-Delvallez M, Fruchart A, Martin GR. Routine evaluation of BACTEC NR-16A and NR-17A media. J Clin Microbiol. 1988 Sep;26(9):1619-22. doi: 10.1128/jcm.26.9.1619-1622.1988. PMID: 3183014; PMCID: PMC266682. 3: Forward KR, Kerr E, Dalton M. An assessment of the anaerobic vial of paired NR 6A and NR 7N Bactec blood cultures. Can J Infect Dis. 1994 Jan;5(1):37-40. doi: 10.1155/1994/612515. PMID: 22346480; PMCID: PMC3250841. 4: Morello JA, Matushek SM, Dunne WM, Hinds DB. Performance of a BACTEC nonradiometric medium for pediatric blood cultures. J Clin Microbiol. 1991 Feb;29(2):359-62. doi: 10.1128/jcm.29.2.359-362.1991. PMID: 2007644; PMCID: PMC269767. 5: Kern W, Kirchner S, Vanek E. Resin versus standard blood culture media used with the new BACTEC automated infrared system: an evaluation in febrile granulocytopenic patients. Zentralbl Bakteriol. 1990 Jun;273(2):156-63. doi: 10.1016/s0934-8840(11)80243-4. PMID: 2400531.