MedKoo Cat#: 123465 | Name: AMC-109

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMC-109 is an antimicrobial peptide memetic.

Chemical Structure

AMC-109
AMC-109
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 123465

Name: AMC-109

CAS#: N/A

Chemical Formula: C43H69N11O3

Exact Mass: 787.5600

Molecular Weight: 788.10

Elemental Analysis: C, 65.53; H, 8.83; N, 19.55; O, 6.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AMC-109; AMC109; AMC 109;
IUPAC/Chemical Name
(S)-2-amino-5-guanidino-N-((S)-1-(((S)-5-guanidino-1-oxo-1-(phenethylamino)pentan-2-yl)amino)-1-oxo-3-(2,5,7-tri-tert-butyl-1H-indol-3-yl)propan-2-yl)pentanamide
InChi Key
ZVOYWSKEBVVLGW-ZDCRTTOTSA-N
InChi Code
InChI=1S/C43H69N11O3/c1-41(2,3)27-23-28-29(35(43(7,8)9)54-34(28)30(24-27)42(4,5)6)25-33(53-36(55)31(44)17-13-20-50-39(45)46)38(57)52-32(18-14-21-51-40(47)48)37(56)49-22-19-26-15-11-10-12-16-26/h10-12,15-16,23-24,31-33,54H,13-14,17-22,25,44H2,1-9H3,(H,49,56)(H,52,57)(H,53,55)(H4,45,46,50)(H4,47,48,51)/t31-,32-,33-/m0/s1
SMILES Code
O=C(N[C@H](C(NCCC1=CC=CC=C1)=O)CCCNC(N)=N)[C@@H](NC([C@@H](N)CCCNC(N)=N)=O)CC2=C(C(C)(C)C)NC3=C2C=C(C(C)(C)C)C=C3C(C)(C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 788.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Laulund AS, Schwartz FA, Christophersen L, Høiby N, Svendsen JSM, Stensen W, Thomsen K, Cavanagh JP, Moser C. Lactoferricin-inspired peptide AMC-109 augments the effect of ciprofloxacin against Pseudomonas aeruginosa biofilm in chronic murine wounds. J Glob Antimicrob Resist. 2022 Jun;29:185-193. doi: 10.1016/j.jgar.2021.12.015. Epub 2021 Dec 23. PMID: 34954415. 2: Håkansson J, Cavanagh JP, Stensen W, Mortensen B, Svendsen JS, Svenson J. In vitro and in vivo antibacterial properties of peptide AMC-109 impregnated wound dressings and gels. J Antibiot (Tokyo). 2021 May;74(5):337-345. doi: 10.1038/s41429-021-00406-5. Epub 2021 Jan 25. PMID: 33495549.