TUG-2304 is a high potent FFA2 antagonist with IC50 values of 3−4 nM in both cAMP and GTPγS assays. TUG-2304 showed favorable physicochemical and pharmacokinetic properties, and the ability to completely inhibit propionateinduced neutrophil migration and respiratory burst.
MedKoo Cat#: 123418
Name: TUG-2304
CAS#: N/A
Chemical Formula: C20H20F3N5O2
Exact Mass: 419.1600
Molecular Weight: 419.41
Elemental Analysis: C, 57.28; H, 4.81; F, 13.59; N, 16.70; O, 7.63
The following data is based on the product molecular weight 419.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
