MedKoo Cat#: 123390 | Name: SRI-22819

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SRI-22819 is NF-ҡB activator for the treatment of ALS. SRI-22819 increases NF-ҡB expression and activation in vitro, but it has poor ADME properties in general and has no oral bioavailability.

Chemical Structure

 SRI-22819
SRI-22819
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 123390

Name: SRI-22819

CAS#: N/A

Chemical Formula: C14H12N4S

Exact Mass: 268.0800

Molecular Weight: 268.34

Elemental Analysis: C, 62.66; H, 4.51; N, 20.88; S, 11.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SRI-22819; SRI 22819; SRI22819
IUPAC/Chemical Name
N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine
InChi Key
AUWIYYMLXLLRIY-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H12N4S/c1-10-5-4-8-16-13(10)18-14-17-12(9-19-14)11-6-2-3-7-15-11/h2-9H,1H3,(H,16,17,18)
SMILES Code
CC1=CC=CN=C1NC2=NC(C3=NC=CC=C3)=CS2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 268.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Mathew B, Ruiz P, Dutta S, Entrekin JT, Zhang S, Patel KD, Simmons MS, Augelli-Szafran CE, Cowell RM, Suto MJ. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS. Eur J Med Chem. 2021 Jan 15;210:112952. doi: 10.1016/j.ejmech.2020.112952. Epub 2020 Oct 22. PMID: 33139114.