ZLY28 is an FXR and FABP1 dual modulator. In a mouse model of NASH, ZLY28 significantly alleviated fatty liver by modulating multiple pathogenic pathways, including lipid metabolism and inflammation. Its therapeutic effects are achieved through the inhibition of FABP1 and activation of the FXR-FGF15 signaling pathway in the ileum. Notably, ZLY28's action is confined to the intestine, which minimizes systemic exposure and reduces potential side effects.
MedKoo Cat#: 123349
Name: ZLY28
CAS#: 3004676-77-8
Chemical Formula: C29H23Cl2NO4
Exact Mass: 519.1000
Molecular Weight: 520.41
Elemental Analysis: C, 66.93; H, 4.45; Cl, 13.62; N, 2.69; O, 12.30
The following data is based on the product molecular weight 520.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
