MedKoo Cat#: 130442 | Name: RasGRP3 ligand 96

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RasGRP3 ligand 96 is a ligand of Ras guanine-releasing protein 3 (RasGRP3) that displays higher selectivity for RasGRP3 as compared to PKC.

Chemical Structure

RasGRP3 ligand 96
RasGRP3 ligand 96
CAS#2229068-13-5

Theoretical Analysis

MedKoo Cat#: 130442

Name: RasGRP3 ligand 96

CAS#: 2229068-13-5

Chemical Formula: C21H25NO5

Exact Mass: 371.1733

Molecular Weight: 371.43

Elemental Analysis: C, 67.91; H, 6.78; N, 3.77; O, 21.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RasGRP3 ligand 96
IUPAC/Chemical Name
(E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl pivalate
InChi Key
NMSQMKXWQOPPRS-NTEUORMPSA-N
InChi Code
InChI=1S/C21H25NO5/c1-20(2,3)19(25)26-13-21(12-23)10-14(18(24)27-21)9-15-11-22(4)17-8-6-5-7-16(15)17/h5-9,11,23H,10,12-13H2,1-4H3/b14-9+
SMILES Code
CC(C)(C)C(OCC(C/C1=C\C2=CN(C)C3=C2C=CC=C3)(CO)OC1=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 371.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Ann J, Czikora A, Saini AS, Zhou X, Mitchell GA, Lewin NE, Peach ML, Blumberg PM, Lee J. α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands. J Med Chem. 2018 Jul 26;61(14):6261-6276. doi: 10.1021/acs.jmedchem.8b00661. Epub 2018 Jul 3. PMID: 29860841.