MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 130436 | Name: YB-0158

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YB-0158 is a β-turn peptidomimetic molecule with high affinity for Sam68, blocking the activity of cancer stem cells, specifically human colorectal cancer stem cells. Cancer stem cells have been postulated to play a role in metastasis and recurrence, with YB-0158 downregulating the transactivation of Wnt, which has been shown to be hyperactivated in cancer stem cells.

Chemical Structure

YB-0158
YB-0158
CAS#1144043-83-3

Theoretical Analysis

MedKoo Cat#: 130436

Name: YB-0158

CAS#: 1144043-83-3

Chemical Formula: C32H32N7Na2O7P

Exact Mass: 703.1896

Molecular Weight: 703.60

Elemental Analysis: C, 54.63; H, 4.58; N, 13.94; Na, 6.53; O, 15.92; P, 4.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
YB-0158; YB0158; YB 0158; Wnt pathway inhibitor 2
IUPAC/Chemical Name
sodium 4-(((6S,9aS)-8-((1H-indazol-7-yl)methyl)-2-allyl-1-(benzylcarbamoyl)-4,7-dioxooctahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl phosphate
InChi Key
BUCIVAHDHKFRLG-QLBXQKMFSA-L
InChi Code
InChI=1S/C32H34N7O7P.2Na/c1-2-15-37-21-29(40)38-27(16-22-11-13-26(14-12-22)46-47(43,44)45)31(41)36(19-25-10-6-9-24-18-34-35-30(24)25)20-28(38)39(37)32(42)33-17-23-7-4-3-5-8-23;;/h2-14,18,27-28H,1,15-17,19-21H2,(H,33,42)(H,34,35)(H2,43,44,45);;/q;2*+1/p-2/t27-,28-;;/m0../s1
SMILES Code
O=P([O-])([O-])OC1=CC=C(C[C@H](N2[C@@](CN3CC4=CC=CC5=C4NN=C5)([H])N(C(NCC6=CC=CC=C6)=O)N(CC=C)CC2=O)C3=O)C=C1.[Na+].[Na+]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 703.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Masibag AN, Bergin CJ, Haebe JR, Zouggar A, Shah MS, Sandouka T, Mendes da Silva A, Desrochers FM, Fournier-Morin A, Benoit YD. Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience. 2021 Nov 14;24(12):103442. doi: 10.1016/j.isci.2021.103442. PMID: 34877499; PMCID: PMC8633986.

View History

U-18666A

U-18666A

New Featured