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MedKoo Cat#: 130421 | Name: CG13250

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CG13250 is a BET bromodomain inhibitor that is orally bioavailable. CG13250 has been shown to be efficacious is a xenograft mouse model of leukemia.

Chemical Structure

CG13250
CG13250
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130421

Name: CG13250

CAS#: N/A

Chemical Formula: C21H19N3O2

Exact Mass: 345.1477

Molecular Weight: 345.40

Elemental Analysis: C, 73.03; H, 5.54; N, 12.17; O, 9.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CG13250; CG 13250; CG-13250
IUPAC/Chemical Name
4-(benzylamino)-6-(3,5-dimethylisoxazol-4-yl)quinolin-2(1H)-one
InChi Key
ZZEQMSXTKAJTLH-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H19N3O2/c1-13-21(14(2)26-24-13)16-8-9-18-17(10-16)19(11-20(25)23-18)22-12-15-6-4-3-5-7-15/h3-11H,12H2,1-2H3,(H2,22,23,25)
SMILES Code
O=C1NC2=C(C=C(C3=C(C)ON=C3C)C=C2)C(NCC4=CC=CC=C4)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 345.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Imayoshi N, Yoshioka M, Chauhan J, Nakata S, Toda Y, Fletcher S, Strovel JW, Takata K, Ashihara E. CG13250, a novel bromodomain inhibitor, suppresses proliferation of multiple myeloma cells in an orthotopic mouse model. Biochem Biophys Res Commun. 2017 Mar 4;484(2):262-268. doi: 10.1016/j.bbrc.2017.01.088. Epub 2017 Jan 20. PMID: 28115161. 2. Chauhan J, Yoshioka M, Pogash S, Strovel JW, Fletcher S. Discovery and anti-tumor activity of 4-(benzylamino)-6-(3,5-dimethylisoxazol-4-yl)quinolin-2(1H)-one (CG13250), a potent, selective and orally bioavailable BET bromodomain inhibitor. Bioorg Med Chem Lett. 2023 Apr 15;86:129220. doi: 10.1016/j.bmcl.2023.129220. Epub 2023 Mar 9. PMID: 36905966.