PTBTK3 | CAS#N/A | BTK inhbitor

MedKoo Cat#: 130420 | Name: PTBTK3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PTBTK3 is a Bruton's tyrosine kinase (BTK) inhibitor for use as a PET radiotracer for the development of BTK inhibitors.

Chemical Structure

PTBTK3

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130420

Name: PTBTK3

CAS#: N/A

Chemical Formula: C27H27F2N5O3

Exact Mass: 507.2082

Molecular Weight: 507.54

Elemental Analysis: C, 63.90; H, 5.36; F, 7.49; N, 13.80; O, 9.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PTBTK3

IUPAC/Chemical Name

N-(4-(6-amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-2-fluorobenzyl)-4-cyclopropyl-2-fluorobenzamide

InChi Key

WMTAKXCJLSCEQM-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H27F2N5O3/c1-3-23(35)34(2)10-11-37-25-24(32-15-33-26(25)30)18-6-7-19(21(28)13-18)14-31-27(36)20-9-8-17(12-22(20)29)16-4-5-16/h3,6-9,12-13,15-16H,1,4-5,10-11,14H2,2H3,(H,31,36)(H2,30,32,33)

SMILES Code

O=C(NCC1=CC=C(C2=NC=NC(N)=C2OCCN(C)C(C=C)=O)C=C1F)C3=CC=C(C4CC4)C=C3F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 507.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Li K, Wang M, Akoglu M, Pollard AC, Klecker JB, Alfonso P, Corrionero A, Prendiville N, Qu W, Parker MFL, Turkman N, Cohen JA, Tonge PJ. Synthesis and Preclinical Evaluation of a Novel Fluorine-18-Labeled Tracer for Positron Emission Tomography Imaging of Bruton's Tyrosine Kinase. ACS Pharmacol Transl Sci. 2023 Feb 10;6(3):410-421. doi: 10.1021/acsptsci.2c00215. PMID: 36926452; PMCID: PMC10012250.