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MedKoo Cat#: 130415 | Name: TTP-8307

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TTP-8307 inhibits viral replication, specifically inhibiting the activity of the oxysterol-binding protein (OSBP) through the PI4KIIIβ-PI4P-OSBP pathway.

Chemical Structure

TTP-8307
TTP-8307
CAS#950225-08-8

Theoretical Analysis

MedKoo Cat#: 130415

Name: TTP-8307

CAS#: 950225-08-8

Chemical Formula: C27H21FN4O

Exact Mass: 436.1699

Molecular Weight: 436.49

Elemental Analysis: C, 74.30; H, 4.85; F, 4.35; N, 12.84; O, 3.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TTP-8307; TTP8307; TTP 8307
IUPAC/Chemical Name
(R)-N-(1-(4-fluorophenyl)ethyl)-3-(2-(isoquinolin-3-yl)-1H-imidazol-5-yl)benzamide
InChi Key
SIBDJDZVNXVLEX-QGZVFWFLSA-N
InChi Code
InChI=1S/C27H21FN4O/c1-17(18-9-11-23(28)12-10-18)31-27(33)21-8-4-7-20(13-21)25-16-30-26(32-25)24-14-19-5-2-3-6-22(19)15-29-24/h2-17H,1H3,(H,30,32)(H,31,33)/t17-/m1/s1
SMILES Code
O=C(N[C@@H](C1=CC=C(F)C=C1)C)C2=CC=CC(C3=CN=C(C4=CC5=C(C=N4)C=CC=C5)N3)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 436.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Roberts BL, Severance ZC, Bensen RC, Le-McClain AT, Malinky CA, Mettenbrink EM, Nuñez JI, Reddig WJ, Blewett EL, Burgett AWG. Differing activities of oxysterol-binding protein (OSBP) targeting anti-viral compounds. Antiviral Res. 2019 Oct;170:104548. doi: 10.1016/j.antiviral.2019.104548. Epub 2019 Jul 2. PMID: 31271764. 2: Albulescu L, Bigay J, Biswas B, Weber-Boyvat M, Dorobantu CM, Delang L, van der Schaar HM, Jung YS, Neyts J, Olkkonen VM, van Kuppeveld FJM, Strating JRPM. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017 Apr;140:37-44. doi: 10.1016/j.antiviral.2017.01.008. Epub 2017 Jan 11. PMID: 28088354. 3: Norder H, De Palma AM, Selisko B, Costenaro L, Papageorgiou N, Arnan C, Coutard B, Lantez V, De Lamballerie X, Baronti C, Solà M, Tan J, Neyts J, Canard B, Coll M, Gorbalenya AE, Hilgenfeld R. Picornavirus non-structural proteins as targets for new anti-virals with broad activity. Antiviral Res. 2011 Mar;89(3):204-18. doi: 10.1016/j.antiviral.2010.12.007. Epub 2011 Jan 12. PMID: 21236302. 4: Arita M, Kojima H, Nagano T, Okabe T, Wakita T, Shimizu H. Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity. J Virol. 2011 Mar;85(5):2364-72. doi: 10.1128/JVI.02249-10. Epub 2010 Dec 22. PMID: 21177810; PMCID: PMC3067798. 5: Arita M, Takebe Y, Wakita T, Shimizu H. A bifunctional anti-enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection. J Gen Virol. 2010 Nov;91(Pt 11):2734-44. doi: 10.1099/vir.0.023374-0. Epub 2010 Jul 21. PMID: 20660150. 6: Aguado L, Thibaut HJ, Priego EM, Jimeno ML, Camarasa MJ, Neyts J, Pérez-Pérez MJ. 9-Arylpurines as a novel class of enterovirus inhibitors. J Med Chem. 2010 Jan 14;53(1):316-24. doi: 10.1021/jm901240p. PMID: 19924996. 7: De Palma AM, Thibaut HJ, van der Linden L, Lanke K, Heggermont W, Ireland S, Andrews R, Arimilli M, Al-Tel TH, De Clercq E, van Kuppeveld F, Neyts J. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrob Agents Chemother. 2009 May;53(5):1850-7. doi: 10.1128/AAC.00934-08. Epub 2009 Feb 23. PMID: 19237651; PMCID: PMC2681499.