MedKoo Cat#: 130401 | Name: KB03-SLF
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

KB03-SLF, an electrophilic PROTAC, is vital in the discovery and exploration of ligandable E3 ligases for applications in targeted protein degradation. KB03-SLF is comprised of FKBP12 (SLF) on one end and a scout fragment on the other.

Chemical Structure

KB03-SLF
KB03-SLF
CAS# 2384184-42-1

Theoretical Analysis

MedKoo Cat#: 130401

Name: KB03-SLF

CAS#: 2384184-42-1

Chemical Formula: C50H63ClF3N5O12

Exact Mass: 1017.4114

Molecular Weight: 1018.52

Elemental Analysis: C, 58.96; H, 6.23; Cl, 3.48; F, 5.60; N, 6.88; O, 18.85

Price and Availability

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5mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
KB03-SLF
IUPAC/Chemical Name
(R)-1-(3-(1-(3-(2-chloroacetamido)-5-(trifluoromethyl)phenyl)-1,5-dioxo-9,12-dioxa-2,6-diazapentadecan-15-amido)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
InChi Key
JXTWMUOLYMSLIA-ZESVVUHVSA-N
InChi Code
InChI=1S/C50H63ClF3N5O12/c1-6-49(2,3)45(63)47(65)59-21-8-7-12-38(59)48(66)71-39(15-13-32-14-16-40(67-4)41(26-32)68-5)33-10-9-11-36(28-33)57-43(61)18-22-69-24-25-70-23-20-55-42(60)17-19-56-46(64)34-27-35(50(52,53)54)30-37(29-34)58-44(62)31-51/h9-11,14,16,26-30,38-39H,6-8,12-13,15,17-25,31H2,1-5H3,(H,55,60)(H,56,64)(H,57,61)(H,58,62)/t38-,39+/m0/s1
SMILES Code
O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCOCCOCCNC(CCNC(C3=CC(C(F)(F)F)=CC(NC(CCl)=O)=C3)=O)=O)=O)=C2)CCC4=CC=C(OC)C(OC)=C4
Appearance
To be determined
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,018.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zhang X, Crowley VM, Wucherpfennig TG, Dix MM, Cravatt BF. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746. doi: 10.1038/s41589-019-0279-5. Epub 2019 Jun 17. PMID: 31209349; PMCID: PMC6592777.