V2043 | CAS# | GS-441524 derivative

MedKoo Cat#: 123206 | Name: V2043

Description:

WARNING: This product is for research use only, not for human or veterinary use.

V2043, also known as ODBG-P-RVn, is a GS-441524 derivative, and an antiviral agent as a potential oral treatment for SARS-CoV-2. V2043 showed that it inhibits SARS-CoV-2 replication in Huh7.5 cells (EC50 = 138 nM) and is orally bioavailable in Syrian hamsters

Chemical Structure

V2043

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 123206

Name: V2043

CAS#: N/A

Chemical Formula: C40H62N5O9P

Exact Mass: 787.4300

Molecular Weight: 787.94

Elemental Analysis: C, 60.97; H, 7.93; N, 8.89; O, 18.27; P, 3.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

V2043; V 2043; V-2043; ODBG P-RVn; ODBG-P-RVn; ODBG-P RVn; C000718607

IUPAC/Chemical Name

((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((R)-2-(benzyloxy)-3-(octadecyloxy)propyl) hydrogen phosphate

InChi Key

JWTGVUMJEVOXGW-RTZKIGCUSA-N

InChi Code

InChI=1S/C40H62N5O9P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-25-50-27-33(51-26-32-21-18-17-19-22-32)28-52-55(48,49)53-29-35-37(46)38(47)40(30-41,54-35)36-24-23-34-39(42)43-31-44-45(34)36/h17-19,21-24,31,33,35,37-38,46-47H,2-16,20,25-29H2,1H3,(H,48,49)(H2,42,43,44)/t33-,35-,37-,38-,40+/m1/s1

SMILES Code

O=P(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@](C#N)(C2=CC=C3N2N=CN=C3N)O1)OC[C@@H](COCCCCCCCCCCCCCCCCCC)OCC4=CC=CC=C4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 787.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lo MK, Shrivastava-Ranjan P, Chatterjee P, Flint M, Beadle JR, Valiaeva N, Schooley RT, Hostetler KY, Montgomery JM, Spiropoulou C. Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524). bioRxiv [Preprint]. 2021 Aug 10:2021.08.06.455494. doi: 10.1101/2021.08.06.455494. Update in: Microbiol Spectr. 2021 Nov 24;:e0153721. PMID: 34401879; PMCID: PMC8366795. 2: Lo MK, Shrivastava-Ranjan P, Chatterjee P, Flint M, Beadle JR, Valiaeva N, Murphy J, Schooley RT, Hostetler KY, Montgomery JM, Spiropoulou CF. Broad- Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524). Microbiol Spectr. 2021 Dec 22;9(3):e0153721. doi: 10.1128/Spectrum.01537-21. Epub 2021 Nov 24. PMID: 34817209; PMCID: PMC8612139.