BAY-1165747, also known as BAY-747, is a Long-Acting potent orally available sGC stimulator for the Treatment of Resistant Hypertension. BAY-747 showed the best overall profile in several in vitro and preclinically relevant in vivo experiments. It was selected as clinical candidate and the pharmacokinetic profile in humans was shown to be suitable for once-daily dosing by demonstrating a sustained effect on blood pressure and heart rate for up to 24 h.
MedKoo Cat#: 123205
Name: BAY-1165747
CAS#: N/A
Chemical Formula: C22H26F2N4O2
Exact Mass: 416.2000
Molecular Weight: 416.47
Elemental Analysis: C, 63.45; H, 6.29; F, 9.12; N, 13.45; O, 7.68
The following data is based on the product molecular weight 416.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
