CPD-1224 is heterobifunctional degrader (proteolysis targeting chimeras, PROTAC). CPD-1224 avoided hemolysis (a feature of detergent-like PROTACs), degraded the otherwise recalcitrant mutant L1196M/G1202R in vivo, and commensurately slowed tumor growth, while the third generation ALK inhibitor drug lorlatinib had no effect.
MedKoo Cat#: 123192
Name: CPD-1224
CAS#: N/A
Chemical Formula: C43H47ClN8O7S
Exact Mass: 854.3000
Molecular Weight: 855.41
Elemental Analysis: C, 60.38; H, 5.54; Cl, 4.14; N, 13.10; O, 13.09; S, 3.75
The following data is based on the product molecular weight 855.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
