Thalidomide-Photoswitch3-NH2 hydrochloride is a vital component in the synthesis of PHOTACs, which are PROTACs whose reversible activation is governed by different wavelengths of light, being rendered inactive in the dark and activated to the cis isomer by irradiation at 390 nm. At wavelengths above 450 nm, the PHOTACs are reversibly inactivated. The conjugate, which consists of a Cereblon (CRBN)-recruiting ligand, an azobenzene photoswitchable crosslinker, and a pendant amine that reacts with an acid on the target warhead, was used in the preparation of PHOTAC-I-10 and PHOTAC-II-6.
MedKoo Cat#: 130386
Name: Thalidomide-Photoswitch3-NH2 hydrochloride
CAS#: N/A
Chemical Formula: C27H23ClN6O6
Exact Mass:
Molecular Weight: 562.97
Elemental Analysis: C, 57.60; H, 4.12; Cl, 6.30; N, 14.93; O, 17.05
The following data is based on the product molecular weight 562.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
