MedKoo Cat#: 130379 | Name: HUN00482
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

HUN00482, also known as Pomalidomide-methylamino-PEG1-NH2 hydrochloride is a building block in the development of protein degraders and PROTAC research. Pomalidomide-methylamino-PEG1-NH2 hydrochloride consists of a Cereblon (CRBN)-recruiting ligand, a linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand.

Chemical Structure

HUN00482
HUN00482
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130379

Name: HUN00482

CAS#: N/A

Chemical Formula: C21H28ClN5O6

Exact Mass: 0.0000

Molecular Weight: 481.93

Elemental Analysis: C, 52.34; H, 5.86; Cl, 7.36; N, 14.53; O, 19.92

Price and Availability

Size Price Availability Quantity
50mg USD 1,100.00 2 Weeks
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Related CAS #
No Data
Synonym
HUN00482; HUN-00482; HUN 00482; Pomalidomide-methylamino-PEG1-NH2 hydrochloride; Pomalidomide-methylamino-PEG1-NH2 HCl
IUPAC/Chemical Name
3-((2-(2-aminoethoxy)ethyl)(methyl)amino)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide hydrochloride
InChi Key
HBXYNGDSINGFDL-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H27N5O6.ClH/c1-25(10-12-32-11-8-22)9-7-17(28)23-14-4-2-3-13-18(14)21(31)26(20(13)30)15-5-6-16(27)24-19(15)29;/h2-4,15H,5-12,22H2,1H3,(H,23,28)(H,24,27,29);1H
SMILES Code
O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCN(CCOCCN)C.[H]Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 481.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Lee B, Kim DG, Lee A, Kim YM, Cui L, Kim S, Choi I. Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug. J Enzyme Inhib Med Chem. 2023 Dec;38(1):51-66. doi: 10.1080/14756366.2022.2135510. PMID: 36305287; PMCID: PMC9621298.