MedKoo Cat#: 123145 | Name: Ac4GalNAz
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ac4GalNAz is an alkyl chain-based PROTAC linker.

Chemical Structure

Ac4GalNAz
Ac4GalNAz
CAS# 653600-56-7

Theoretical Analysis

MedKoo Cat#: 123145

Name: Ac4GalNAz

CAS#: 653600-56-7

Chemical Formula: C16H22N4O10

Exact Mass: 430.1300

Molecular Weight: 430.37

Elemental Analysis: C, 44.65; H, 5.15; N, 13.02; O, 37.17

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Ac4GalNAz; 653600-56-7; MFCD26961128;
IUPAC/Chemical Name
(3R,4R,5R,6R)-6-(acetoxymethyl)-3-(2-azidoacetamido)tetrahydro-2H-pyran-2,4,5-triyl triacetate
InChi Key
HGMISDAXLUIXKM-YJUJGKJLSA-N
InChi Code
InChI=1S/C16H22N4O10/c1-7(21)26-6-11-14(27-8(2)22)15(28-9(3)23)13(16(30-11)29-10(4)24)19-12(25)5-18-20-17/h11,13-16H,5-6H2,1-4H3,(H,19,25)/t11-,13-,14+,15-,16?/m1/s1
SMILES Code
O=C(N[C@H]1C(OC(C)=O)O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O)CN=[N+]=[N-]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 430.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mongis A, Piller F, Piller V. Coupling of Immunostimulants to Live Cells through Metabolic Glycoengineering and Bioorthogonal Click Chemistry. Bioconjug Chem. 2017 Apr 19;28(4):1151-1165. doi: 10.1021/acs.bioconjchem.7b00042. Epub 2017 Mar 28. PMID: 28297599. 2: Yang X, Tang Y, Zhang X, Hu Y, Tang YY, Hu LY, Li S, Xie Y, Zhu D. Fluorometric visualization of mucin 1 glycans on cell surfaces based on rolling- mediated cascade amplification and CdTe quantum dots. Mikrochim Acta. 2019 Oct 26;186(11):721. doi: 10.1007/s00604-019-3840-8. PMID: 31655930. 3: Sheta R, Woo CM, Roux-Dalvai F, Fournier F, Bourassa S, Droit A, Bertozzi CR, Bachvarov D. A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells. J Proteomics. 2016 Aug 11;145:91-102. doi: 10.1016/j.jprot.2016.04.009. Epub 2016 Apr 17. PMID: 27095597; PMCID: PMC5436706. 4: Ling Z, Xing Y, Jacome ER, Fok SW, Ren X. Bioorthogonal Labeling and Chemoselective Functionalization of Lung Extracellular Matrix. Bio Protoc. 2021 Feb 20;11(4):e3922. doi: 10.21769/BioProtoc.3922. PMID: 33732809; PMCID: PMC7952949. 5: Zhu Y, Willems LI, Salas D, Cecioni S, Wu WB, Foster LJ, Vocadlo DJ. Tandem Bioorthogonal Labeling Uncovers Endogenous Cotranslationally O-GlcNAc Modified Nascent Proteins. J Am Chem Soc. 2020 Sep 16;142(37):15729-15739. doi: 10.1021/jacs.0c04121. Epub 2020 Sep 1. PMID: 32870666. 6: Ruff SM, Keller S, Wieland DE, Wittmann V, Tovar GEM, Bach M, Kluger PJ. clickECM: Development of a cell-derived extracellular matrix with azide functionalities. Acta Biomater. 2017 Apr 1;52:159-170. doi: 10.1016/j.actbio.2016.12.022. Epub 2016 Dec 10. PMID: 27965173. 7: Sheta R, Roux-Dalvai F, Woo CM, Fournier F, Bourassa S, Bertozzi CR, Droit A, Bachvarov D. Proteomic dataset for altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells. Data Brief. 2016 May 30;8:342-9. doi: 10.1016/j.dib.2016.05.060. PMID: 27331112; PMCID: PMC4908283. 8: Pan H, Li W, Chen Z, Luo Y, He W, Wang M, Tang X, He H, Liu L, Zheng M, Jiang X, Yin T, Liang R, Ma Y, Cai L. Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor. Bioact Mater. 2020 Oct 9;6(4):951-962. doi: 10.1016/j.bioactmat.2020.09.025. PMID: 33102938; PMCID: PMC7560591. 9: Maciej-Hulme ML, Dubaissi E, Shao C, Zaia J, Amaya E, Flitsch SL, Merry CLR. Selective Inhibition of Heparan Sulphate and Not Chondroitin Sulphate Biosynthesis by a Small, Soluble Competitive Inhibitor. Int J Mol Sci. 2021 Jun 29;22(13):6988. doi: 10.3390/ijms22136988. PMID: 34209670; PMCID: PMC8269443. 10: Guo Z, Li H, Qin W. [Precise identification of O-linked β-N-acetylglucosamine peptides based on O-mesitylenesulfonylhydroxylamine elimination reaction]. Se Pu. 2021 Nov;39(11):1182-1190. Chinese. doi: 10.3724/SP.J.1123.2020.12024. PMID: 34677013; PMCID: PMC9404036. 11: Woo CM, Felix A, Byrd WE, Zuegel DK, Ishihara M, Azadi P, Iavarone AT, Pitteri SJ, Bertozzi CR. Development of IsoTaG, a Chemical Glycoproteomics Technique for Profiling Intact N- and O-Glycopeptides from Whole Cell Proteomes. J Proteome Res. 2017 Apr 7;16(4):1706-1718. doi: 10.1021/acs.jproteome.6b01053. Epub 2017 Feb 28. PMID: 28244757; PMCID: PMC5507588. 12: Jolly AL, Agarwal P, Metruccio MME, Spiciarich DR, Evans DJ, Bertozzi CR, Fleiszig SMJ. Corneal surface glycosylation is modulated by IL-1R and Pseudomonas aeruginosa challenge but is insufficient for inhibiting bacterial binding. FASEB J. 2017 Jun;31(6):2393-2404. doi: 10.1096/fj.201601198R. Epub 2017 Feb 21. PMID: 28223334; PMCID: PMC5434651.