MedKoo Cat#: 130355 | Name: CBTF
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CBTF is a a heterobifunctional reagent that is often used for the conjugation of antibodies, participating in amine-to-thiol coupling reactions. The 3-arylpropionitrile (APN) group of CBTF allows for the production of stable conjugates.

Chemical Structure

CBTF
CBTF
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130355

Name: CBTF

CAS#: N/A

Chemical Formula: C16H4F4NNaO5S

Exact Mass: 0.0000

Molecular Weight: 421.25

Elemental Analysis: C, 45.62; H, 0.96; F, 18.04; N, 3.33; Na, 5.46; O, 18.99; S, 7.61

Price and Availability

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50mg USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
CBTF;
IUPAC/Chemical Name
sodium 4-((4-(cyanoethynyl)benzoyl)oxy)-2,3,5,6-tetrafluorobenzenesulfonate
InChi Key
YFJYSJRZDOWXDH-UHFFFAOYSA-M
InChi Code
InChI=1S/C16H5F4NO5S.Na/c17-10-12(19)15(27(23,24)25)13(20)11(18)14(10)26-16(22)9-5-3-8(4-6-9)2-1-7-21;/h3-6H,(H,23,24,25);/q;+1/p-1
SMILES Code
O=C(C1=CC=C(C=C1)C#CC#N)OC2=C(C(F)=C(C(F)=C2F)S(=O)([O-])=O)F.[Na+]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 421.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Kolodych S, Koniev O, Baatarkhuu Z, Bonnefoy JY, Debaene F, Cianférani S, Van Dorsselaer A, Wagner A. CBTF: new amine-to-thiol coupling reagent for preparation of antibody conjugates with increased plasma stability. Bioconjug Chem. 2015 Feb 18;26(2):197-200. doi: 10.1021/bc500610g. Epub 2015 Jan 23. PMID: 25614935.